Donald Spratt

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Associate Professor

Clark University

United States

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Recent Grants

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Structure and Mechanism of HECT E3 Ubiquitin Ligases

Open Date: 2017-09-20

Close Date: 2020-08-31

Grant: Close

Structure and Mechanism of an E2-E3 Enzyme Complex in Ubiquitylation

Open Date: 2012-01-01

Close Date: 2012-12-31

Grant: Close

Structure and mechanism of the E2 enzyme CDC34 in Ubiquitylation

Open Date: 2011-04-01

Close Date: 2012-03-31

Grant: Close

Structure and mechanism of the E2 enzyme CDC34 in Ubiquitylation

Open Date: 2010-04-01

Close Date: 2011-03-31

Grant: Close

Structure and mechanism of the E2 enzyme CDC34 in Ubiquitylation

Open Date: 2009-04-01

Close Date: 2010-03-31

Articles (10)

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2022

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2022

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2021

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2021

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2021

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2021

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2021

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2020

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2020

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2020

Collaborators (2)

Stephen D. Barr

Western University

CANADA

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Noel Lazo

Professor

Clark University

UNITED STATES

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Donald Spratt

Research Interests

Explore related searches

Contact this professor

Recent Grants

Articles (10)

Redefining the catalytic HECT domain boundaries for the HECT E3 ubiquitin ligase family

Extending the Catalytic HECT Domain Boundaries for the HECT E3 Ubiquitin Ligase HACE1 Increases Solubility and Enzymatic Activity

Differential Effects of Polyphenols on Insulin Proteolysis by the Insulin-Degrading Enzyme

Intersection of Redox Chemistry and Ubiquitylation: Post-Translational Modifications Required for Maintaining Cellular Homeostasis and Neuroprotection

HERC5 and the ISGylation Pathway: Critical Modulators of the Antiviral Immune Response

Structural Insights into Ankyrin Repeat-Containing Proteins and Their Influence in Ubiquitylation

Exploring the Roles of HERC2 and the NEDD4L HECT E3 Ubiquitin Ligase Subfamily in p53 Signaling and the DNA Damage Response

An Angelman syndrome substitution in the HECT E3 ubiquitin ligase C-terminal Lobe of E6AP affects protein stability and activity

HECT E3 ubiquitin ligases – emerging insights into their biological roles and disease relevance

Crystal structure of the catalytic C-lobe of the HECT-type ubiquitin ligase E6AP

Collaborators (2)

Stephen D. Barr

Noel Lazo

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