Doron Merkler

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University of Geneva

Switzerland

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Recent Grants

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Deciphering transcriptional regulators of T cell fate decisions in CNS autoimmunity

Open Date: 2021-04-01

Close Date: 2025-03-31

Grant: Close

Molecular pathology of anti-viral T cell responses in the central nervous system

Open Date: 2020-08-01

Close Date: 2025-07-31

Grant: Close

Drivers and signatures of neuronal dysfunction in neuroinflammation

Open Date: 2019-05-01

Close Date: 2023-04-30

Grant: Close

Compartmentalized T cell memory in brain viral infection and autoimmunity

Open Date: 2017-04-01

Close Date: 2021-03-31

Grant: Close

The alarmin interleukin-33 in infection, immunity and autoimmunity

Open Date: 2016-01-01

Close Date: 2018-12-31

Articles (21)

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Collaborators (15)

Christian Vollmar

UCL Institute of Neurology, University College London

UNITED KINGDOM

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Regina Rose Reimann

University of Zurich

SWITZERLAND

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Ioana Sandu

Karolinska Institutet

SWEDEN

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Jeremiah Bernier-Latmani

University of Lausanne

SWITZERLAND

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Manuel A Friese

University Medical Center Hamburg-Eppendorf

GERMANY

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Nicolas Liaudet

Université de Genève

SWITZERLAND

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Pietro Cacialli

Assistant Professor

University of Bologna

ITALY

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Sven Rottenberg

University of Bern

SWITZERLAND

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Christoph Scheiermann

University of Geneva

SWITZERLAND

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Tatiana V. Petrova

SWITZERLAND

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Daniel Pinschewer

Professor at University of Basel

University of Basel

SWITZERLAND

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Raphael Kuhn

ETH Zürich

SWITZERLAND

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Julien BERTRAND

Associate Professor

University of Geneva

SWITZERLAND

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stephanie hugues

Associate Professor

University of Geneva

SWITZERLAND

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Nicole Joller

Professor for Immunology

University of Zurich

SWITZERLAND

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Doron Merkler

Research Interests

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Recent Grants

Articles (21)

SV2A-PET imaging uncovers cortical synapse loss in multiple sclerosis

Oligodendrocyte-derived IL-33 regulates self-reactive CD8+ T cells in CNS autoimmunity

Neuronal pSTAT1 hallmarks synaptic pathology in autoimmune encephalitis against intracellular antigens

BCAS1-positive oligodendrocytes enable efficient cortical remyelination in multiple sclerosis

The Many Faces of Myxopapillary Ependymomas

AQP4-specific T cells determine lesion localization in the CNS in a model of NMOSD

Durable lymphocyte subset elimination upon a single dose of AAV-delivered depletion antibody dissects immune control of chronic viral infection

Long survival in a patient with fumarate hydratase mutation-associated glioma

The NR4A2/VGF pathway fuels inflammation-induced neurodegeneration via promoting neuronal glycolysis

STING orchestrates the neuronal inflammatory stress response in multiple sclerosis

Synergistic prostaglandin E synthesis by myeloid and endothelial cells promotes fetal hematopoietic stem cell expansion in vertebrates

Single-cell immune repertoire sequencing of B and T cells in murine models of infection and autoimmunity.

IFN-γ–dependent tumor-antigen cross-presentation by lymphatic endothelial cells promotes their killing by T cells and inhibits metastasis

Tissue-resident memory CD8 <sup>+</sup> T cells cooperate with CD4 <sup>+</sup> T cells to drive compartmentalized immunopathology in the CNS

G9a dictates neuronal vulnerability to inflammatory stress via transcriptional control of ferroptosis.

Towards a national strategy for digital pathology in Switzerland.

Neurodegenerative phagocytes mediate synaptic stripping in Neuro-HIV

Comparative multi-tissue profiling reveals extensive tissue-specificity in transcriptome reprogramming during thermal adaptation.

Selective plasticity of callosal neurons in the adult contralesional cortex following murine traumatic brain injury.

Tissue-resident CD8 T cells in central nervous system inflammatory diseases: present at the crime scene and …guilty.

CD4<sup>+</sup>c-Met<sup>+</sup>Itgα4<sup>+</sup> T cell subset promotes murine neuroinflammation.

Collaborators (15)

Christian Vollmar

Regina Rose Reimann

Ioana Sandu

Jeremiah Bernier-Latmani

Manuel A Friese

Nicolas Liaudet

Pietro Cacialli

Sven Rottenberg

Christoph Scheiermann

Tatiana V. Petrova

Daniel Pinschewer

Raphael Kuhn

Julien BERTRAND

stephanie hugues

Nicole Joller

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