Dorota Sylwia Rogacka

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assistant professor

Gdańsk University of Technology, Faculty of Chemistry

Poland

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Dorota Sylwia Rogacka is an assistant professor at the Faculty of Chemistry, University of Gdańsk, Poland. Her research primarily focuses on the metabolic regulation of podocytes in diabetic conditions, investigating key signaling pathways and mitochondrial dynamics. Recent articles include studies on the role of various receptors and enzymes like TGR5 and lactate dehydrogenase A in the context of glucose metabolism and podocyte function. She also explores the implications of hyperglycemia and insulin signaling on podocyte health and pathology.

Recent Grants

Grant: Close

Metabolizm glikogenu i glukoneogeneza w komórkach podocytarnych kłębuszka nerkowego: wpływ na funkcje podocytów w normoglikemii i hiperglikemii

Open Date: 2021-12-01

Close Date: 2025-12-01

Grant: Close

Rola zależnej od cGMP ścieżki sygnałowania komórkowego w regulacji ekspresji i aktywności deacetylazy SIRT1: nowy mechanizm indukcji insulinooporności podocytów eksponowanych na wysokie stężenie glukozy

Open Date: 2017-08-09

Close Date: 2020-08-08

Grant: Close

Znaczenie sirtuin i kinazy białkowej AMPK w insulinooporności podocytów.

Open Date: 2013-02-11

Close Date: 2016-02-10

Grant: Close

Rola wysokich stężeń glukozy oraz przemian glukozaminy w procesie autofagii w podocytach: znaczenie kinazy białkowej AMPK

Open Date: 2011-05-04

Close Date: 2014-05-03

Grant: Close

Mechanizm insulinooporności podocytów: znaczenie przemian heksozamin i kinazy białkowej AMPK

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Close Date:

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2022

Collaborators (7)

Agnieszka Piwkowska

assistant professor

University of Gdańsk

POLAND

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Moin Saleem

University of Bristol

UNITED KINGDOM

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Marlena Typiak

Assistant Professor

University of Gdańsk

POLAND

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Patrycja Rachubik

Mossakowski Medical Research Institute, Polish Academy of Sciences

POLAND

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Maria Szrejder

Mossakowski Medical Research Institute, Polish Academy of Sciences

POLAND

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Adam Lesner

professor

University of Gdańsk

POLAND

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Magdalena Narajczyk

University of Gdańsk

POLAND

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Dorota Sylwia Rogacka

Research Interests

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About

Recent Grants

Articles (19)

Role of bile acid-dependent Takeda G-coupled protein receptor 5 (TGR5) in regulating AMPK expression in human podocytes

Role of lactate dehydrogenase A in the regulation of podocyte metabolism and glucose uptake under hyperglycemic conditions

Role of Metabolic Sensor GPR81/HCAR1 in Diabetic Podocytes: Downregulated Lipolysis Results in the Deterioration of Glomerular Filtration Barrier

Involvement of ADAM17-Klotho Crosstalk in High Glucose-Induced Alterations of Podocyte Function

ADAM10 as a major activator of reactive oxygen species production and klotho shedding in podocytes under diabetic conditions

Lactate regulates respiratory efficiency and mitochondrial dynamics in primary rat podocytes

Hyperglycemia – A culprit of podocyte pathology in the context of glycogen metabolism

Insulin induces bioenergetic changes and alters mitochondrial dynamics in podocytes

Biological Evaluation of a Rhodium(III) Bipyridylsulfonamide Complex: Effects on Mitochondrial Dynamics and Cytoskeletal Remodeling in Breast Cancer Cells

Role of lysosomes in insulin signaling and glucose uptake in cultured rat podocytes

Pit 1 transporter (SLC20A1) as a key factor in the NPP1‐mediated inhibition of insulin signaling in human podocytes

The Role of PKGIα and AMPK Signaling Interplay in the Regulation of Albumin Permeability in Cultured Rat Podocytes

The Role of PKGI alpha and AMPK Signaling Interplay in the Regulation of Albumin Permeability in Cultured Rat Podocytes

Role of L-lactate as an energy substrate in primary rat podocytes under physiological and glucose deprivation conditions

Inhibition of phosphodiesterase 5A by tadalafil improves SIRT1 expression and activity in insulin-resistant podocytes

Inhibition of phosphodiesterase 5A by tadalafil improves SIRT1 expression and activity in insulin-resistant podocytes

beta-Aminoisobutyric acid (L-BAIBA) is a novel regulator of mitochondrial biogenesis and respiratory function in human podocytes

β-Aminoisobutyric acid (L-BAIBA) is a novel regulator of mitochondrial biogenesis and respiratory function in human podocytes

Insulin controls cytoskeleton reorganization and filtration barrier permeability via the PKGIα-Rac1-RhoA crosstalk in cultured rat podocytes

Collaborators (7)

Agnieszka Piwkowska

Moin Saleem

Marlena Typiak

Patrycja Rachubik

Maria Szrejder

Adam Lesner

Magdalena Narajczyk

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