Douglas Graham

Chief

Children's Healthcare of Atlanta

United States

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About

Douglas Graham serves as Chief at Children's Healthcare of Atlanta, United States. His research primarily focuses on targeted cancer therapies, particularly involving MERTK inhibition, and its role in various leukemias and Ewing Sarcoma. Recent publications highlight innovative strategies including dual inhibitors and nanoformulations aimed at enhancing immunotherapy and chemoresistance in pediatric oncology.

Articles (10)

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2024

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2024

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2024

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2024

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2023

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2023

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2023

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2023

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2023

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2023

Collaborators (2)

Sunil Raikar

Emory University and Children's Healthcare of Atlanta

UNITED STATES

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Mohamed Ahmed Mohamed Emam Mansour

University of Porto

PORTUGAL

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Douglas Graham

Research Interests

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Articles (10)

Discovery of Novel Macrocyclic MERTK/AXL Dual Inhibitors

MERTK Inhibition as a Targeted Novel Cancer Therapy

MERTK Is a Potential Therapeutic Target in Ewing Sarcoma

MERTK inhibition selectively activates a DC – T-cell axis to provide anti-leukemia immunity

Constitutively Synergistic Multiagent Drug Formulations Targeting MERTK, FLT3, and BCL-2 for Treatment of AML

Development of constitutively synergistic nanoformulations to enhance chemosensitivity in T-cell leukemia

In vitro vascular differentiation system efficiently produces natural killer cells for cancer immunotherapies

Inhibiting efferocytosis reverses macrophage-mediated immunosuppression in the leukemia microenvironment

Pediatric T-cell acute lymphoblastic leukemia blast signature and MRD associated immune environment changes defined by single cell transcriptomics analysis

Single-cell RNA sequencing distinctly characterizes the wide heterogeneity in pediatric mixed phenotype acute leukemia

Collaborators (2)

Sunil Raikar

Mohamed Ahmed Mohamed Emam Mansour

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