Dr. Jessica Dieckhoff

Head of Genetic Toxicology

Merck KGaA

Germany

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About

Dr. Jessica Dieckhoff is the Head of Genetic Toxicology at Merck in Germany. Her research focuses on the safety limits of pharmaceuticals, particularly through advanced techniques such as error-corrected next-generation sequencing and benchmark dose analysis. Recent studies led by her include analyzing the carcinogenic potential of N-nitrosamines and exploring metabolic activation pathways in experimental models.

Articles (3)

Year:

2025

Year:

2025

Year:

2024

Collaborators (1)

Jakub Kostal

Assistant Professor

George Washington University

UNITED STATES

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Dr. Jessica Dieckhoff

Research Interests

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About

Articles (3)

Deriving safe limits for N-nitroso-bisoprolol by error-corrected next-generation sequencing (ecNGS) and benchmark dose (BMD) analysis, integrated with QM modeling and CYP-docking analysis

HESI GTTC ring trial: Concordance between Ames and rodent carcinogenicity outcomes for N-nitrosamines (NAs) with rat and hamster metabolic conditions

Metabolic activation of short-chain alkyl N-nitrosamines using Aroclor 1254 or phenobarbital/beta-naphthoflavone-induced rat or hamster S9 – A comparative analysis

Collaborators (1)

Jakub Kostal

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