Edyta Gendaszewska-Darmach

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TUL Professor

Poland

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About

Edyta Gendaszewska-Darmach is a Professor at Lodz University of Technology, Faculty of Biotechnology and Food Sciences in Poland. Her research focuses on the role of N-acyl glycines and staple peptides in metabolic diseases, the effectiveness of PROTACs in protein degradation, and the use of injectable formulations for tissue engineering. Additionally, she explores the insulinotropic activity of natural compounds and their impact on insulin secretion through various mechanisms.

Recent Grants

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Unravelling the controversial role of palmitoleic acid in the dietary prophylaxis of carbohydrate and lipid homeostasis disorders

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Targeted degradation of Rab geranylgeranyl transferase as a new approach to investigate prenylation of Rab GTPases

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Articles (20)

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2024

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2024

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2024

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2024

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2024

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2024

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2024

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2023

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2023

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2023

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2022

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2022

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2022

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2022

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2021

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2021

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2021

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2021

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2021

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2020

Collaborators (11)

Agnieszka Krzemińska

Assistant Professor

Lodz University of Technology

POLAND

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Grzegorz Dąbrowski

University of Warmia and Mazury in Olsztyn

POLAND

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Agnieszka J. Pietrzyk-Brzezinska

Lodz University of Technology

POLAND

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Anna Drzazga

Københavns Universitet

DENMARK

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Dawid Stawski

professor

Lodz University of Technology

POLAND

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Katarzyna M. Błażewska

Associate Professor

Lodz University of Technology

POLAND

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Marcin Szustak

Lecturer

Lodz University of Technology

POLAND

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Joanna Pietrasik

Lodz University of Technology

POLAND

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Anna Gliszczyńska

Wroclaw University of Environmental and Life Sciences

POLAND

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Vignesh Kumaravel

Lodz University of Technology

POLAND

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Michał Puchalski

Lodz University of Technology

POLAND

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Edyta Gendaszewska-Darmach

Research Interests

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About

Recent Grants

Articles (20)

Injectable Liposome‐Loaded Hydrogel Formulations with Controlled Release of Curcumin and α‐Tocopherol for Dental Tissue Engineering

Lysophosphatidylcholines Enriched with cis and trans Palmitoleic Acid Regulate Insulin Secretion via GPR119 Receptor

Stapled peptides as potential therapeutics for diabetes and other metabolic diseases

N-acyl glycines produced by commensal bacteria potentiate GLP-1 secretion as GPCR ligands

The impact of E3 ligase choice on PROTAC effectiveness in protein kinase degradation

Double-modified, thio and methylene ATP analogue facilitates wound healing in vitro and in vivo

The impact of selected xanthophylls on oil hydrolysis by pancreatic lipase: in silico and in vitro studies

Targeting reversible post-translational modifications with PROTACs: a focus on enzymes modifying protein lysine and arginine residues

The insulinotropic activity of oleosomes prepared from various sea buckthorn cultivars in mouse and human pancreatic β cell lines

Trans-palmitoleic acid, a dairy fat biomarker, stimulates insulin secretion and activates G protein-coupled receptors with a different mechanism from the cis isomer

Rational design, optimization, and biological evaluation of novel α-Phosphonopropionic acids as covalent inhibitors of Rab geranylgeranyl transferase

Protein Prenyltransferases and Their Inhibitors: Structural and Functional Characterization

Evaluation of the anti-diabetic activity of sea buckthorn pulp oils prepared with different extraction methods in human islet EndoC-betaH1 cells

Development of an electroactive biopolymer-based membrane and characterization of mechanical actuator properties for applications in electromechanical smart products

Targeting Small GTPases and Their Prenylation in Diabetes Mellitus

Extracellular Nucleotides Affect the Proangiogenic Behavior of Fibroblasts, Keratinocytes, and Endothelial Cells

Composition of flesh lipids and oleosome yield optimization of selected sea buckthorn (Hippophae rhamnoides L.) cultivars grown in Poland.

Nanocellulose-Based Scaffolds for Chondrogenic Differentiation and Expansion.

Isoprenoid Derivatives of Lysophosphatidylcholines Enhance Insulin and GLP-1 Secretion through Lipid-Binding GPCRs

Formation of βTC3 and MIN6 Pseudoislets Changes the Expression Pattern of Gpr40, Gpr55, and Gpr119 Receptors and Improves Lysophosphatidylcholines-Potentiated Glucose-Stimulated Insulin Secretion

Collaborators (11)

Agnieszka Krzemińska

Grzegorz Dąbrowski

Agnieszka J. Pietrzyk-Brzezinska

Anna Drzazga

Dawid Stawski

Katarzyna M. Błażewska

Marcin Szustak

Joanna Pietrasik

Anna Gliszczyńska

Vignesh Kumaravel

Michał Puchalski

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