Elias Arnér

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Karolinska Institutet

Sweden

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Recent Grants

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Redox regulation in the hepatostat

Open Date: 2016-09-30

Close Date: 2019-04-30

Grant: Close

Cancer redox-targeting redox pathways for improved cancer therapy

Open Date: 2016-07-01

Close Date: 2021-06-01

Grant: Close

Selenoproteins and redox signaling in cancer

Open Date: 2016-01-01

Close Date: 2018-12-01

Grant: Close

Stretching the genetic code - targeted insertion of selenocysteine into recombinant proteins for biomedical applications

Open Date: 2015-01-01

Close Date: 2017-12-31

Grant: Close

Stretching the genetic code - targeted insertion of selenocysteine into recombinant proteins for biomedical applications

Open Date: 2015-01-01

Close Date: 2017-12-01

Articles (14)

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2024

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2024

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2023

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2023

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2023

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2023

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2022

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2022

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2022

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2021

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2021

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2021

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2021

Year:

2021

Collaborators (7)

Isabelle Magalhaes

Karolinska Institutet

SWEDEN

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Qing Cheng

Karolinska Institutet

SWEDEN

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Stina Wickström

Karolinska Institutet

SWEDEN

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Radosveta Gencheva

Karolinska Institutet

SWEDEN

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Andreas Lundqvist

Karolinska Institutet

SWEDEN

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Albert van der Vliet

University of Vermont

UNITED STATES

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David Wink

Acting Deputy Chief

National Cancer Institute

UNITED STATES

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Elias Arnér

Research Interests

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Contact this professor

Recent Grants

Articles (14)

Endogenous electrophiles and peroxymonocarbonate can link tyrosine phosphorylation cascades with the cytosolic TXNRD1 selenoprotein and the KEAP1/NRF2 system

Piperazine-Fused Cyclic Disulfides Unlock High-Performance Bioreductive Probes of Thioredoxins and Bifunctional Reagents for Thiol Redox Biology

Development of an assay pipeline for the discovery of novel small molecule inhibitors of human glutathione peroxidases GPX1 and GPX4

The ferroptosis inducing compounds RSL3 and ML162 are not direct inhibitors of GPX4 but of TXNRD1

Arsenic exposure and increased C-reactive protein are independently associated with lower erythrocyte glutathione peroxidase activity in Bangladeshi children

TXNL1 has dual functions as a redox active thioredoxin-like protein as well as an ATP- and redox-independent chaperone

Thioredoxin reductase selenoproteins from different organisms as potential drug targets for treatment of human diseases

Targeting of Nrf2 improves antitumoral responses by human NK cells, TIL and CAR T cells during oxidative stress

Cyclic 5-membered disulfides are not selective substrates of thioredoxin reductase, but are opened nonspecifically

Comprehensive chemical proteomics analyses reveal that the new TRi-1 and TRi-2 compounds are more specific thioredoxin reductase 1 inhibitors than auranofin

Selective, Modular Probes for Thioredoxins Enabled by Rational Tuning of a Unique Disulfide Structure Motif

Molecular Basis for the Interactions of Human Thioredoxins with Their Respective Reductases

Comment on “Evidence that the ProPerDP method is inadequate for protein persulfidation detection due to lack of specificity”

Qualitative Differences in Protection of PTP1B Activity by the Reductive Trx1 or TRP14 Enzyme Systems upon Oxidative Challenges with Polysulfides or H2O2 Together with Bicarbonate

Collaborators (7)

Isabelle Magalhaes

Qing Cheng

Stina Wickström

Radosveta Gencheva

Andreas Lundqvist

Albert van der Vliet

David Wink

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