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Elke Krueger

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Director

University Medicine Greifswald

Germany

Research Interests

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Professors in Germany Professors in Biochemistry Biochemistry professors in Germany

Recent Grants

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Deciphering the link between proteostatic control by the ubiquitin-proteasome system and ferroptosis in lymphocytes

Open Date: 2024-01-01

Close Date:

Grant: Close

Dissecting the mechanisms linking proteasome function to mitochondrial proteostasis

Open Date: 2024-01-01

Close Date:

Grant: Close

Meeting the Challenges of Chronic Age-Related Diseases in Rural Areas

Open Date: 2022-01-01

Close Date:

Grant: Close

The function and functional interaction of APN / CD13 and PAR2 in the development and progression of colon cancer

Open Date: 2021-01-01

Close Date:

Grant: Close

GRK 2719: Proteases in pathogen and host: importance in inflammation and infection – RTG-PRO

Open Date: 2021-01-01

Close Date:

Articles (20)

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Collaborators (22)

Geeske van Woerden

Associate professor

Erasmus University Rotterdam

NETHERLANDS

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Roland Eils

University of Heidelberg Bioquant

GERMANY

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Peter Landgraf

Otto-von-Guericke Universität Magdeburg

GERMANY

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Heike Junker

University of Greifswald

GERMANY

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Victor Puelles

Aarhus University

DENMARK

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Anna Mª Cueto-González

Médico Consulta Genética Clínica

Hospital Universitari Vall d'Hebron

SPAIN

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Alexander Bartelt

Else Kröner Fresenius Professor

Technical University of Munich

GERMANY

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Frank Heppner

Director

Charité - Universitätsmedizin Berlin

GERMANY

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Tzung-Chien Hsieh

University Hospital Bonn

GERMANY

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Naveed Ishaque

Professor

Berlin Institute of Health at Charité - Universitätsmedizin Berlin

GERMANY

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Florian Heidel

Professor, Director

Universitätsmedizin Greifswald

GERMANY

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Marie-Pierre Bousquet

Institute of Pharmacology and Structural Biology

FRANCE

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Stéphane Bézieau

Université de Nantes

FRANCE

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Frederic Laumonnier

Team Leader, Research Director

INSERM

FRANCE

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Elke Hammer

University Medicine Greifswald

GERMANY

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Jonas Franz

Neuropathologist

University of Göttingen

GERMANY

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Uwe Völker

Porf, Head of Department

Universitätsmedizin Greifswald

GERMANY

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Michael Lammers

University of Greifswald

GERMANY

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Michael W. M Kühn

Professor of Medicine

University Medical Center of the Johannes Gutenberg University Mainz

GERMANY

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Soeren Lukassen

Junior research group leader

Charité - Universitätsmedizin Berlin

GERMANY

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Sylvia Stracke

Head of Nephrology

University Medicine Greifswald

GERMANY

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Andreas Kuss

Universitätsprofessor

Universitätsmedizin Greifswald

GERMANY

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Elke Krueger

Research Interests

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Recent Grants

Articles (20)

Molecular mechanisms in rare proteasomopathies

Activating the NFE2L1-ubiquitin-proteasome system by DDI2 protects from ferroptosis

Staphylococcal SplA and SplB serine proteases target ubiquitin(-like) specific proteases

The immunoproteasome disturbs neuronal metabolism and drives neurodegeneration in multiple sclerosis.

Investigating the neuronal role of the proteasomal ATPase subunit gene PSMC5 in neurodevelopmental proteasomopathies.

Expression and DNA methylation of 20S proteasome subunits as prognostic and resistance markers in cancer

A De Novo Dominant-Negative PSMB8 Mutation Causes Severe CANDLE/PRAAS Due to Arrested Proteasome Biogenesis

Proteomic and transcriptomic profiling of brainstem, cerebellum and olfactory tissues in early- and late-phase COVID-19

Loss-of-Function Variants in CUL3 Cause a Syndromic Neurodevelopmental Disorder.

DDI2 protease controls embryonic development and inflammation via TCF11/NRF1.

PSMD11 loss-of-function variants correlate with a neurobehavioral phenotype, obesity, and increased interferon response.

Biallelic USP14 variants cause a syndromic neurodevelopmental disorder.

A recurrent missense variant in the E3 ubiquitin ligase substrate recognition subunit FEM1B causes a rare syndromic neurodevelopmental disorder.

The proteasome modulates endocytosis specifically in glomerular cells to promote kidney filtration.

Global Protein Profiling in Processed Immunohistochemistry Tissue Sections

PSMC3 proteasome subunit variants are associated with neurodevelopmental delay and type I interferon production

Representing Sex and Gender Information in Biomedical Research.

Immunoproteasome function maintains oncogenic gene expression in KMT2A-complex driven leukemia.

Identification of eight novel proteasome variants in five unrelated cases of proteasome-associated autoinflammatory syndromes (PRAAS).

Gain-of-function variants in the <i>KDF1</i> gene cause hidradenitis suppurativa associated with ectodermal dysplasia by stabilizing IκB kinase α

Collaborators (22)

Geeske van Woerden

Roland Eils

Peter Landgraf

Heike Junker

Victor Puelles

Anna Mª Cueto-González

Alexander Bartelt

Frank Heppner

Tzung-Chien Hsieh

Naveed Ishaque

Florian Heidel

Marie-Pierre Bousquet

Stéphane Bézieau

Frederic Laumonnier

Elke Hammer

Jonas Franz

Uwe Völker

Michael Lammers

Michael W. M Kühn

Soeren Lukassen

Sylvia Stracke

Andreas Kuss

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