Elwira Chrobak at Medical University of Silesia - Research Interests, Publications & Academic Profile

Elwira Chrobak

Medical University of Silesia

Poland

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Research Interests

Organic Chemistry

100%

Pharmaceutical Chemistry

100%

Heterocyclic Chemistry

90%

Natural Products Chemistry

80%

Chemical Biology

70%

Aromatic Compounds

40%

Phenolic Compound

40%

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Articles20

Synthesis, Pharmacokinetic Profile, Anticancer Activity and Toxicity of the New Amides of Betulonic Acid—In Silico and In Vitro Study

Article Link

Year:

2024

Assessment of Bioavailability Parameters of Mono- and Bistriazole Derivatives of Propynoylbetulin

Article Link

Year:

2024

Derivatives of Betulin and Betulinic Acid Containing a Phosphonate Group—In Silico Studies and Preliminary In Vitro Assessment of Antiviral Activity

Article Link

Year:

2024

Design, Synthesis and Biological Evaluation of Quinoline-8-Sulfonamides as Inhibitors of the Tumor Cell-Specific M2 Isoform of Pyruvate Kinase: Preliminary Study

Article Link

Year:

2023

28-O-Acetyl-3-O′-(prop-2-enoyl)betulin

Article Link

Year:

2023

Modification of 6,7-Dichloro-5,8-Quinolinedione at C2 Position: Synthesis, Quantum Chemical Properties, and Activity against DT-Diaphorase Enzyme

Article Link

Year:

2023

Application of chemometric methods for determination the lipophilicity of pentacyclic triterpene derivatives

Article Link

Year:

2023

Synthesis, Pharmacological Properties, and Potential Molecular Mechanisms of Antitumor Activity of Betulin and Its Derivatives in Gastrointestinal Cancers

Article Link

Year:

2023

Antiproliferative and Cytotoxic Properties of Propynoyl Betulin Derivatives against Human Ovarian Cancer Cells: In Vitro Studies

Article Link

Year:

2023

The Influence of Betulin Derivatives EB5 and ECH147 on the Expression of Selected TGFβ Superfamily Genes, TGFβ1, GDF15 and BMP2, in Renal Proximal Tubule Epithelial Cells

Article Link

Year:

2023

5,8-Quinolinedione Attached to Quinone Derivatives: XRD Diffraction, Fourier Transform Infrared Spectra and Computational Analysis

Article Link

Year:

2023

28-O-Acetyl-3-O’-(Phenylpropynoyl)Betulin

Article Link

Year:

2023

Crystal Structure and Spectroscopic Analysis of 3-Diethoxyphosphoryl-28-[1-(1-deoxy-β-D-glucopyranosyl)-1H-1,2,3-triazol-4-yl]carbonylbetulin

Article Link

Year:

2023

Synthesis and Anticancer Activity of Indole-Functionalized Derivatives of Betulin

Article Link

Year:

2022

New Betulin Derivatives with Nitrogen Heterocyclic Moiety—Synthesis and Anticancer Activity In Vitro

Article Link

Year:

2022

Betulin Acid Ester Derivatives Inhibit Cancer Cell Growth by Inducing Apoptosis through Caspase Cascade Activation: A Comprehensive In Vitro and In Silico Study

Article Link

Year:

2022

Lipophilicity and ADMET Analysis of Quinoline-1,4-quinone Hybrids

Article Link

Year:

2022

28-[1-(3-(Propionyloxy)propyl)-1H-1,2,3-triazol-4-yl]carbonylbetulin

Article Link

Year:

2022

3′-[4-({[3β,28-Bis(acetyloxy)lup-20(29)-en-30-yl]oxy}carbonyl)-1H-1,2,3-triazol-1-yl]-3′-deoxythymidine

Article Link

Year:

2022

Hybrids of 1,4-quinone with quinoline derivatives: synthesis, biological activity, and molecular docking with DT-diaphorase (NQO1).

Article Link

Year:

2022

Collaborators14

Joanna Gola

associate professor

Medical University of Silesia

POLAND

Janusz Kasperczyk

Professor, Head of Chair and Department of Biopharmacy

Medical University of Silesia

POLAND

Artur Beberok

Medical University of Silesia

POLAND

Grzegorz Boryczka

Medical University of Silesia

POLAND

Stefan Baron

Professor

Medical University of Silesia

POLAND

Stanisław Boryczka

Medical University of Silesia

POLAND

Piotr Paduszyński

scientist, lecturer

Medical University of Silesia

POLAND

BARBARA STRZALKA-MROZIK

Medical University of Silesia, Faculty of Pharmaceutical Sciences in Sosnowiec

POLAND

Monika Kadela-Tomanek

Medical University of Silesia

POLAND

Justyna Hermanowicz

assistant professor

Medical University of Białystok

POLAND

Katarzyna Bober-Majnusz

Medical University of Silesia

POLAND

Zuzanna Rzepka

Medical University of Silesia

POLAND

Dorota Wrześniok

Professor

Medical University of Silesia

POLAND

Ewa Bębenek

Medical University of Silesia

POLAND

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Elwira Chrobak

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Research Interests

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Articles20

Synthesis, Pharmacokinetic Profile, Anticancer Activity and Toxicity of the New Amides of Betulonic Acid—In Silico and In Vitro Study

Assessment of Bioavailability Parameters of Mono- and Bistriazole Derivatives of Propynoylbetulin

Derivatives of Betulin and Betulinic Acid Containing a Phosphonate Group—In Silico Studies and Preliminary In Vitro Assessment of Antiviral Activity

Design, Synthesis and Biological Evaluation of Quinoline-8-Sulfonamides as Inhibitors of the Tumor Cell-Specific M2 Isoform of Pyruvate Kinase: Preliminary Study

28-<i>O</i>-Acetyl-3-<i>O</i>′-(prop-2-enoyl)betulin

Modification of 6,7-Dichloro-5,8-Quinolinedione at C2 Position: Synthesis, Quantum Chemical Properties, and Activity against DT-Diaphorase Enzyme

Application of chemometric methods for determination the lipophilicity of pentacyclic triterpene derivatives

Synthesis, Pharmacological Properties, and Potential Molecular Mechanisms of Antitumor Activity of Betulin and Its Derivatives in Gastrointestinal Cancers

Antiproliferative and Cytotoxic Properties of Propynoyl Betulin Derivatives against Human Ovarian Cancer Cells: In Vitro Studies

The Influence of Betulin Derivatives EB5 and ECH147 on the Expression of Selected TGFβ Superfamily Genes, <i>TGFβ1</i>, <i>GDF15</i> and <i>BMP2</i>, in Renal Proximal Tubule Epithelial Cells

5,8-Quinolinedione Attached to Quinone Derivatives: XRD Diffraction, Fourier Transform Infrared Spectra and Computational Analysis

28-<i>O</i>-Acetyl-3-<i>O</i>’-(Phenylpropynoyl)Betulin

Crystal Structure and Spectroscopic Analysis of 3-Diethoxyphosphoryl-28-[1-(1-deoxy-β-D-glucopyranosyl)-1H-1,2,3-triazol-4-yl]carbonylbetulin

Synthesis and Anticancer Activity of Indole-Functionalized Derivatives of Betulin

New Betulin Derivatives with Nitrogen Heterocyclic Moiety—Synthesis and Anticancer Activity In Vitro

Betulin Acid Ester Derivatives Inhibit Cancer Cell Growth by Inducing Apoptosis through Caspase Cascade Activation: A Comprehensive In Vitro and In Silico Study

Lipophilicity and ADMET Analysis of Quinoline-1,4-quinone Hybrids

28-[1-(3-(Propionyloxy)propyl)-1<i>H</i>-1,2,3-triazol-4-yl]carbonylbetulin

3′-[4-({[3β,28-Bis(acetyloxy)lup-20(29)-en-30-yl]oxy}carbonyl)-1<i>H</i>-1,2,3-triazol-1-yl]-3′-deoxythymidine

Hybrids of 1,4-quinone with quinoline derivatives: synthesis, biological activity, and molecular docking with DT-diaphorase (NQO1).

Collaborators14

Joanna Gola

Janusz Kasperczyk

Artur Beberok

Grzegorz Boryczka

Stefan Baron

Stanisław Boryczka

Piotr Paduszyński

BARBARA STRZALKA-MROZIK

Monika Kadela-Tomanek

Justyna Hermanowicz

Katarzyna Bober-Majnusz

Zuzanna Rzepka

Dorota Wrześniok

Ewa Bębenek

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