Enrico De Smaele

Full Professor MED04

Sapienza University of Rome

Italy

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About

Enrico De Smaele is a Full Professor at Sapienza University of Rome, Italy. His research primarily focuses on cancer biology, with recent publications addressing mechanisms of resistance to cancer therapies, the role of specific proteins in tumor development, and the effects of various signaling pathways on cancer progression. His work includes investigating therapeutic strategies for colorectal cancer and medulloblastoma, as well as exploring the interactions between immune cells and the tumor microenvironment.

Articles (13)

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2024

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2024

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2023

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2023

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2023

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2023

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2023

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2023

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2022

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2022

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2021

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2021

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2021

Collaborators (17)

Roberto Bei

ITALY

Enrico De Smaele

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Articles (13)

MYC upstream region orchestrates resistance to PI3K inhibitors in cancer cells through FOXO3a-mediated autophagic adaptation

SALL4 is a CRL3<sup>REN/KCTD11</sup> substrate that drives Sonic Hedgehog-dependent medulloblastoma

SCF and IL-33 regulate mouse mast cell phenotypic and functional plasticity supporting a pro-inflammatory microenvironment

Hedgehog-GLI and Notch Pathways Sustain Chemoresistance and Invasiveness in Colorectal Cancer and Their Inhibition Restores Chemotherapy Efficacy

KCTD1 is a new modulator of the KCASH family of Hedgehog suppressors

Combined inhibition of polyamine metabolism and eIF5A hypusination suppresses colorectal cancer growth through a converging effect on MYC translation

The inhibition of IRE1alpha/XBP1 axis prevents EBV-driven lymphomagenesis in NSG mice

β-arrestin1-E2F1-ac axis regulates physiological apoptosis and cell cycle exit in cellular models of early postnatal cerebellum

Combined treatment with inhibitors of ErbB Receptors and Hh signaling pathways is more effective than single treatment in reducing the growth of malignant mesothelioma both in vitro and in vivo.

A gene dosage-dependent effect unveils NBS1 as both a haploinsufficient tumour suppressor and an essential gene for SHH-medulloblastoma

The emerging role of the KCTD proteins in cancer

Functional cooperation between ASK1 and p21Waf1/Cip1 in the balance of cell-cycle arrest, cell death and tumorigenesis of stressed keratinocytes

Downregulation of miR‐326 and its host gene β‐arrestin1 induces pro‐survival activity of E2F1 and promotes medulloblastoma growth

Collaborators (17)

Roberto Bei

Hidenori Ichijo

Zein Mersini Besharat

Gianluca CANETTIERI

Sonia Coni

Federica Barbagallo

Miriam GAGGIANESI

MARY ANNA VENNERI

Agnese Po

Laura Di Magno

Elisabetta Ferretti

Mara Cirone

LUCIA DI MARCOTULLIO

Isao Naguro

Rosa MOLFETTA

Daniela Nardozi

Loredana Cifaldi

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