Ernesto FEDELE

Full Professor of Pharmacology

University of Genoa

Italy

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Ernesto Fedele is a Full Professor of Pharmacology at the University of Genoa, Italy. His research focuses on Alzheimer's disease, particularly the role of the exposome, anti-amyloid therapies, and the effects of phosphodiesterase 4D inhibition. He has contributed significantly to the understanding of neurodegenerative diseases through recent publications on microRNA biomarkers and memory enhancers for Alzheimer's dementia.

Articles (12)

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2025

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2024

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2023

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2023

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2022

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2022

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2022

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2021

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2021

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2021

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2020

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2020

Collaborators (2)

Roberta Ricciarelli

ITALY

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Giambattista Bonanno

Full Professor

University of Genoa

ITALY

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Ernesto FEDELE

Research Interests

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Articles (12)

The Impact of the Exposome on Alzheimer’s Disease: The Influence of Nutrition

Amelioration of functional and histopathological consequences after spinal cord injury through phosphodiesterase 4D (PDE4D) inhibition

Ablation of specific long PDE4D isoforms increases neurite elongation and conveys protection against amyloid-β pathology

Anti-Amyloid Therapies for Alzheimer’s Disease and the Amyloid Cascade Hypothesis

Selective inhibition of phosphodiesterase 4D increases tau phosphorylation at Ser214 residue

A New Bistable Switch Model of Alzheimer’s Disease Pathogenesis

MicroRNA Alteration, Application as Biomarkers, and Therapeutic Approaches in Neurodegenerative Diseases

Nearly 30 Years of Animal Models to Study Amyotrophic Lateral Sclerosis: A Historical Overview and Future Perspectives

Memory Enhancers for Alzheimer’s Dementia: Focus on cGMP

Protein kinase G phosphorylates the Alzheimer's disease‐associated tau protein at distinct Ser/Thr sites

Acute and Chronic Dopaminergic Depletion Differently Affect Motor Thalamic Function

cGMP favors the interaction between APP and BACE1 by inhibiting Rab5 GTPase activity

Collaborators (2)

Roberta Ricciarelli

Giambattista Bonanno

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