Ernst Schonbrunn

Senior member & Professor

Moffitt Cancer Center

United States

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Ernst Schonbrunn is a Senior member and Professor at Moffitt Cancer Center in the United States. His research primarily focuses on the development of novel inhibitors targeting various cancer-related proteins, including CBP/P300, JAK2, and CDK2/cyclin complexes. He is also actively exploring new therapeutic avenues such as non-hormonal female contraceptives and structural biology techniques to enhance inhibitor selectivity.

Articles (9)

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2021

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2021

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2021

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2020

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2020

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2020

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2020

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2020

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2020

Collaborators (2)

Jeffrey Jensen

Oregon Health & Science University

UNITED STATES

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Carol Hanna

Research Assistant Professor

Oregon National Primate Research Center

UNITED STATES

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Ernst Schonbrunn

Research Interests

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Articles (9)

Development of Dimethylisoxazole-Attached Imidazo[1,2-<i>a</i>]pyridines as Potent and Selective CBP/P300 Inhibitors.

Structural Insights into JAK2 Inhibition by Ruxolitinib, Fedratinib, and Derivatives Thereof.

Tetrahydroindazole inhibitors of CDK2/cyclin complexes.

Development of WEE2 kinase inhibitors as novel non-hormonal female contraceptives that target meiosis†.

New inhibitors for the BPTF bromodomain enabled by structural biology and biophysical assay development.

Inhibition of p53 DNA binding by a small molecule protects mice from radiation toxicity.

MDMX inhibits casein kinase 1α activity and stimulates Wnt signaling.

NMR Analyses of Acetylated H2A.Z Isoforms Identify Differential Binding Interactions with the Bromodomain of the NURF Nucleosome Remodeling Complex.

Structural Basis of Inhibitor Selectivity in the BRD7/9 Subfamily of Bromodomains.

Collaborators (2)

Jeffrey Jensen

Carol Hanna

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