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Esther Wehrle

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Focus Area Leader Bone Biology

AO Research Institute Davos

Switzerland

Research Interests

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Professors in Switzerland Professors in Tissue Engineering Tissue Engineering professors in Switzerland

Recent Grants

Grant: Open

Mechanistic understanding of fracture non-unions

Open Date: 2024-06-01

Close Date: 2027-05-01

Grant: Open

Development of an in vitro micro-vascular invasion model of hypertrophic cartilage.

Open Date: 2024-06-01

Close Date: 2027-05-01

Grant: Close

Spatial transcriptomics

Open Date: 2024-01-01

Close Date: 2024-01-01

Grant: Open

Sustained local ionic homeostatic imbalance to trigger ectopic bone formation and boost orthotopic bone formation (SLIHI4BONE)

Open Date: 2023-05-01

Close Date: 2027-04-30

Grant: Close

In vivo mechanomics approach for early individualized mechanical intervention therapies during fracture healing

Open Date: 2022-08-01

Close Date: 2025-07-01

Articles (17)

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2023

AO Research Institute Davos

SWITZERLAND

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Markus Laubach

Ludwig-Maximilians-Universität München

GERMANY

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Natascha Drude

Unit Lead

Charité - Universitätsmedizin Berlin

GERMANY

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Sarah Weschke

Berlin Institute of Health at Charité - Universitätsmedizin Berlin

GERMANY

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Ulf Toelch

Berlin Institute of Health at Charité - Universitätsmedizin Berlin

GERMANY

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Nicolai Spicher

Associate Professor

Technical University of Denmark

DENMARK

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Esther Wehrle

Research Interests

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Recent Grants

Articles (17)

Animal models for critical-sized long-bone defects and long-bone non-union: a scoping review

Advances in Spatial Transcriptomics in Bone

Spatial transcriptomics in bone mechanomics: Exploring the mechanoregulation of fracture healing in the era of spatial omics

Clinical translation of 3D-printed patient-specific bone implants: a consensus statement.

Transient Early Mechanical Loading Induces Hypertrophic Chondrocyte Differentiation of Human Mesenchymal Stromal Cells

Age- and sex-specific deterioration on bone and osteocyte lacuno-canalicular network in a mouse model of premature aging

Influence of Age on Fracture Healing in Young and Middle‐Aged Mice in a Proximal Femur Fracture Model

Elucidating the mechano-molecular dynamics of TRAP activity using CRISPR/Cas9 mediated fluorescent reporter mice

Daily rhythms in metabolic and locomotor behaviour of prematurely ageing PolgA mice

In Vitro Induction of Hypertrophic Chondrocyte Differentiation of Naïve MSCs by Strain

Unveiling frailty: comprehensive and sex-specific characterization in prematurely aging PolgA mice.

Clinical management and innovation in fracture non-union.

Protocol for preparing formalin-fixed paraffin-embedded musculoskeletal tissue samples from mice for spatial transcriptomics

Prognostic and therapeutic potential of microRNAs for fracture healing processes and non‐union fractures: A systematic review

Mouse models of accelerated aging in musculoskeletal research for assessing frailty, sarcopenia, and osteoporosis - A review.

Corrigendum: Alginate dependent changes of physical properties in 3D bioprinted cell-laden porous scaffolds affect cell viability and cell morphology (2019<i>Biomed. Mater.</i>14065009).

Trabecular bone remodeling in the aging mouse: A micro-multiphysics agent-based <i>in silico</i> model using single-cell mechanomics.

Collaborators (15)

Ralph Müller

Xiao-Hua Qin

Mario Morgenstern

Penny Atkins

Boris Schmitz

Marina Rubert

Neashan Mathavan

Elena Della Bella

Michael Friebe

Martin Stoddart

Markus Laubach

Natascha Drude

Sarah Weschke

Ulf Toelch

Nicolai Spicher

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