Fabien Toulgoat

Acyl fluorides have emerged as versatile reagents in various synthetic endeavors, offering a range of advantages over their counterparts, acyl chlorides. This study delves into the properties and reactivity of acyl fluorides, particularly their reaction with amines and alcohols, to elucidate their distinct characteristics. We also introduce a facile and practical synthesis of acyl fluorides from a stable solution of CF 3 O − salt. Additionally, we establish an efficient one‐pot process for the direct preparation of amides or esters from corresponding acids and amines or alcohols, showcasing the remarkable efficiency of acyl fluorides in these transformations.

Invited for this issue's Front Cover is the group of Frédéric. R. Leroux. The cover picture illustrates the potential of difluoromethoxylated ketones as building blocks for accessing challenging structures bearing the key OCF 2 H motif. These are represented here by a rocket, a highly technical achievement. Obviously, a parallel can be drawn between the building block strategy and a famous construction game. On the righthand side of the cover we can see the rocket heading towards a cell, highlighting the importance of fluorinated molecules in life sciences. Cover design by A. Loison. Read the full text of the article at 10.1002/ejoc.202300695 .