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Frances Bashore

Research Assistant Professor

University of North Carolina at Chapel Hill

United States

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Research Interests

Biochemistry

100%

Pharmaceutical Chemistry

60%

Chemical Biology

50%

Kinase Biology

50%

Protein Chemistry

40%

Assay Development

30%

Anti-aging Research

20%

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Articles14

Discovery and Characterization of a Chemical Probe for Cyclin-Dependent Kinase-Like 2

Article Link

Year:

2024

Development of SYK NanoBRET cellular target engagement assays for gain–of–function variants

Article Link

Year:

2024

Characterization of covalent inhibitors that disrupt the interaction between the tandem SH2 domains of SYK and FCER1G phospho-ITAM

Article Link

Year:

2024

Discovery of a Potent and Selective Naphthyridine-Based Chemical Probe for Casein Kinase 2

Article Link

Year:

2023

Modulation of tau tubulin kinases (TTBK1 and TTBK2) impacts ciliogenesis

Article Link

Year:

2023

Identification of a chemical probe for lipid kinase phosphatidylinositol-5-phosphate 4-kinase gamma (PI5P4Kγ)

Article Link

Year:

2023

Discovery and characterization of a specific inhibitor of serine-threonine kinase cyclin-dependent kinase-like 5 (CDKL5) demonstrates role in hippocampal CA1 physiology

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Year:

2023

PROTAC Linkerology Leads to an Optimized Bivalent Chemical Degrader of Polycomb Repressive Complex 2 (PRC2) Components

Article Link

Year:

2023

Discovery of FERM domain protein–protein interaction inhibitors for MSN and CD44 as a potential therapeutic approach for Alzheimer’s disease

Article Link

Year:

2023

Protein proximity networks and functional evaluation of the casein kinase 1 gamma family reveal unique roles for CK1γ3 in WNT signaling

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Year:

2022

AD Informer Set: Chemical tools to facilitate Alzheimer's disease drug discovery

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Year:

2022

Use of AD Informer Set compounds to explore validity of novel targets in Alzheimer's disease pathology

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Year:

2022

Identification and Utilization of a Chemical Probe to Interrogate the Roles of PIKfyve in the Lifecycle of β-Coronaviruses.

Article Link

Year:

2022

Exploration of Aberrant E3 Ligases Implicated in Alzheimer's Disease and Development of Chemical Tools to Modulate Their Function.

Article Link

Year:

2021

Collaborators9

David H. Drewry

University of North Carolina at Chapel Hill

UNITED STATES

Jesse Wiley

Associate Professor

University of Kansas

UNITED STATES

Michael Major

Professor

Washington University in St. Louis

UNITED STATES

Opher Gileadi

Head, Protein Sciences

Karolinska Institutet

SWEDEN

Vittorio Katis

University of Oxford

UNITED KINGDOM

Timothy Willson

Professor

University of North Carolina at Chapel Hill

UNITED STATES

James Dunford

University of Oxford

UNITED KINGDOM

Alison Axtman

Research Associate Professor

University of North Carolina at Chapel Hill

UNITED STATES

William Bradshaw

University of Oxford

UNITED KINGDOM

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