Frances Bashore

Research Assistant Professor

University of North Carolina at Chapel Hill

United States

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Frances Bashore is a Research Assistant Professor at The University of North Carolina at Chapel Hill, USA. Her research focuses on the discovery and characterization of chemical probes and inhibitors related to various kinases and phosphatidylinositol-5-phosphate 4-kinase gamma, with implications for neurodegenerative diseases such as Alzheimer’s. Recent publications highlight her contributions to understanding cellular target engagement assays and the role of specific kinases in cellular physiology and disease pathology.

Articles (14)

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2024

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2024

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2024

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2023

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2023

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2023

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2023

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2022

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2022

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2022

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2022

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2021

Collaborators (9)

David H. Drewry

University of North Carolina at Chapel Hill

UNITED STATES

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Jesse Wiley

Associate Professor

University of Kansas

UNITED STATES

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Michael Major

Professor

Washington University in St. Louis

UNITED STATES

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Opher Gileadi

Head, Protein Sciences

Karolinska Institutet

SWEDEN

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Vittorio Katis

University of Oxford

UNITED KINGDOM

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Timothy Willson

Professor

University of North Carolina at Chapel Hill

UNITED STATES

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James Dunford

University of Oxford

UNITED KINGDOM

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Alison Axtman

Research Associate Professor

University of North Carolina at Chapel Hill

UNITED STATES

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William Bradshaw

University of Oxford

UNITED KINGDOM

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Frances Bashore

Research Interests

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Articles (14)

Discovery and Characterization of a Chemical Probe for Cyclin-Dependent Kinase-Like 2

Development of SYK NanoBRET cellular target engagement assays for gain–of–function variants

Characterization of covalent inhibitors that disrupt the interaction between the tandem SH2 domains of SYK and FCER1G phospho-ITAM

Discovery of a Potent and Selective Naphthyridine-Based Chemical Probe for Casein Kinase 2

Modulation of tau tubulin kinases (TTBK1 and TTBK2) impacts ciliogenesis

Identification of a chemical probe for lipid kinase phosphatidylinositol-5-phosphate 4-kinase gamma (PI5P4Kγ)

Discovery and characterization of a specific inhibitor of serine-threonine kinase cyclin-dependent kinase-like 5 (CDKL5) demonstrates role in hippocampal CA1 physiology

PROTAC Linkerology Leads to an Optimized Bivalent Chemical Degrader of Polycomb Repressive Complex 2 (PRC2) Components

Discovery of FERM domain protein–protein interaction inhibitors for MSN and CD44 as a potential therapeutic approach for Alzheimer’s disease

Protein proximity networks and functional evaluation of the casein kinase 1 gamma family reveal unique roles for CK1γ3 in WNT signaling

AD Informer Set: Chemical tools to facilitate Alzheimer's disease drug discovery

Use of AD Informer Set compounds to explore validity of novel targets in Alzheimer's disease pathology

Identification and Utilization of a Chemical Probe to Interrogate the Roles of PIKfyve in the Lifecycle of β-Coronaviruses.

Exploration of Aberrant E3 Ligases Implicated in Alzheimer's Disease and Development of Chemical Tools to Modulate Their Function.

Collaborators (9)

David H. Drewry

Jesse Wiley

Michael Major

Opher Gileadi

Vittorio Katis

Timothy Willson

James Dunford

Alison Axtman

William Bradshaw

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