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Francis Jacob

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Co-Group leader Ovarian Cancer Research

University Hospital Basel

Switzerland

Research Interests

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Professors in Switzerland Professors in Cell Biology Cell Biology professors in Switzerland

Recent Grants

Grant: Close

Shedding light on the dark matter of tumor hybrid cells

Open Date: 2024-03-01

Close Date: 2025-02-28

Grant: Close

Innovative ovarian cancer zPDX models for prediction of treatment regimen outcomes in precision medicine

Open Date: 2022-02-01

Close Date: 2025-01-31

Grant: Close

Functional characterization of bisecting GlcNAc-dependent signalling pathways for the intervention of serous ovarian cancer omental metastasis

Open Date: 2016-10-01

Close Date: 2020-09-30

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Collaborators (20)

Roger Schibli

Prof. at ETH Zürich

ETH Zürich

SWITZERLAND

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Josef Pasulka

Czech Academy of Sciences, Institute of Molecular Genetics

CZECH REPUBLIC

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Andreas Wicki

University of Zurich

SWITZERLAND

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Jack Kuipers

Senior Scientist

ETH Zürich

SWITZERLAND

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Mitchell Levesque

SWITZERLAND

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Bernd Bodenmiller

University of Zurich

SWITZERLAND

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Sara Ricardo

Associate Professor

Instituto Universitário de Ciências da Saúde

PORTUGAL

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Michael Schmid

Head of Bioinformatics and LabIT

University Hospital of Zurich

SWITZERLAND

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Michael Prummer

Head of Biostatistics

ETH Zürich

SWITZERLAND

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An Coosemans

Katholieke Universiteit Leuven

BELGIUM

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Daniel Stekhoven

Managing Director

ETH Zürich

SWITZERLAND

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Nageswara Rao Tata

Group Leader

Kantonsspital St. Gallen

SWITZERLAND

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Alexandre Theocharides

Department of Medical Oncology, Inselspital, Bern University Hospital

SWITZERLAND

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Ricardo Coelho

Scientist- Project leader

University Hospital Basel

SWITZERLAND

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Niko Beerenwinkel

Prof.

ETH Zurich

SWITZERLAND

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Jonathan De Roo

Professor at University of Basel

University of Basel

SWITZERLAND

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Ewelina Bartoszek

Kavli Institute for Systems Neuroscience at the Norwegian University of Science and Technology

NORWAY

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Salvatore Piscuoglio

Associate Professor

Humanitas University

ITALY

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Tarun Mehra

University Hospital of Zurich

SWITZERLAND

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Viola Heinzelmann-Schwarz

University Hospital Basel

SWITZERLAND

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Francis Jacob

Research Interests

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Recent Grants

Articles (20)

Two-step PEG-based surface functionalization of gold nanoparticles enables specific SERS imaging of EGFR in an ovarian cancer cell model

A tumor profiling resource for ovarian cancer: insights into chemotherapy-driven heterogeneity and personalized treatment strategy

Comparative cost analysis of a diagnostic multi-omics platform for decision support in advanced cancer – results from the Tumor Profiler Melanoma project

The chromatin guardian ATRX is a strong prognostic biomarker in melanoma

P-cadherin overexpression is associated with early transformation of the Fallopian tube epithelium and aggressiveness of tubo-ovarian high-grade serous carcinoma

Integrating Formalin-Fixed, Paraffin-Embedded–Derived Whole-Genome Sequencing into Routine Molecular Pathology

Phosphoproteomics Reveals L1CAM-Associated Signaling Networks in High-Grade Serous Ovarian Carcinoma: Implications for Radioresistance and Tumorigenesis

De novo detection of somatic variants in high-quality long-read single-cell RNA sequencing data

Publisher Correction: Feasibility of multiomics tumor profiling for guiding treatment of melanoma

Feasibility of multiomics tumor profiling for guiding treatment of melanoma

Standardization of Suspension and Imaging Mass Cytometry Single-Cell Readouts for Clinical Decision Making.

Ovarian cancer metastasis to the human omentum disrupts organ homeostasis and induces fundamental tissue reprogramming

High-resolution imaging mass cytometry to map subcellular structures

Histopathology-based protein multiplex generation using deep learning

Chemotherapy Drives Tertiary Lymphoid Structures That Correlate with ICI-Responsive TCF1<SUP>+</SUP>CD8<SUP>+</SUP> T Cells in Metastatic Ovarian Cancer

(161)Tb-Based Anti-L1CAM Radioimmunotherapy Shows Superior Efficacy in Eliminating Ovarian Cancer Stem Cells Compared with (177)Lu in Preclinical Models of Ovarian Cancer

Perfusion-based ex vivo culture of frozen ovarian cancer tissues with preserved tumor microenvironment.

Single-cell landscape of innate and acquired drug resistance in acute myeloid leukemia.

Protocol for quantifying drug sensitivity in 3D patient-derived ovarian cancer models

Nuclear and cytosolic fractions of SOX2 synergize as transcriptional and translational co-regulators of cell fate.

Collaborators (20)

Roger Schibli

Josef Pasulka

Andreas Wicki

Jack Kuipers

Mitchell Levesque

Bernd Bodenmiller

Sara Ricardo

Michael Schmid

Michael Prummer

An Coosemans

Daniel Stekhoven

Nageswara Rao Tata

Alexandre Theocharides

Ricardo Coelho

Niko Beerenwinkel

Jonathan De Roo

Ewelina Bartoszek

Salvatore Piscuoglio

Tarun Mehra

Viola Heinzelmann-Schwarz

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