Franco Izzo

Assistant Professor

Icahn School of Medicine at Mount Sinai

United States

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About

Franco Izzo is an Assistant Professor at the Icahn School of Medicine at Mount Sinai, located in the United States. His research interests encompass clonal evolution, single-cell multi-omics, and hematopoietic differentiation, with recent publications focusing on leukemia development and myeloproliferative neoplasms. Notable works include studies on DNMT3A mutations in clonal hematopoiesis and the role of RUNX1 in leukemia stem cell maintenance.

Articles (11)

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2025

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2024

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2024

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2022

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2022

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2022

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2020

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2020

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2020

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2020

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2020

Collaborators (5)

Ryan Schreiner

Assistant Professor

Weill Cornell Medicine

UNITED STATES

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Irene Ghobrial

Professor of Medicine

Dana-Farber Cancer Institute

UNITED STATES

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Federico Gaiti

University Health Network

CANADA

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Won Jun Kim

Weill Cornell Medical College

UNITED STATES

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Tamara Prieto

Weill Cornell Medicine

UNITED STATES

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Franco Izzo

Research Interests

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Articles (11)

The Crossroads of Clonal Evolution, Differentiation Hierarchy, and Ontogeny in Leukemia Development

Mapping genotypes to chromatin accessibility profiles in single cells

Jak2V617F Reversible Activation Shows Its Essential Requirement in Myeloproliferative Neoplasms

Single-cell multi-omics of human clonal hematopoiesis reveals that DNMT3A R882 mutations perturb early progenitor states through selective hypomethylation.

Specification of fetal liver endothelial progenitors to functional zonated adult sinusoids requires c-Maf induction.

A BAX door to venetoclax resistance

DNA methylation disruption reshapes the hematopoietic differentiation landscape

Canonical ErbB-2 isoform and ErbB-2 variant c located in the nucleus drive triple negative breast cancer growth.

Nuclear PDCD4 Expression Defines a Subset of Luminal B-Like Breast Cancers with Good Prognosis.

Acute Myeloid Leukemia iPSCs Reveal a Role for RUNX1 in the Maintenance of Human Leukemia Stem Cells.

Inhibition of EZH2 Catalytic Activity Selectively Targets a Metastatic Subpopulation in Triple-Negative Breast Cancer.

Collaborators (5)

Ryan Schreiner

Irene Ghobrial

Federico Gaiti

Won Jun Kim

Tamara Prieto

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