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Frank Gonzalez

Principal Investigator

National Cancer Institute

United States

Research Interests

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Articles (16)

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2026

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2026

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2025

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2023

Collaborators (5)

Weiya Zhang

University of Nottingham

UNITED KINGDOM

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Xi Huang

Senior Scientist

Hospital for Sick Children

CANADA

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Pamela Hoodless

Professor

The University of British Columbia

CANADA

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Atif Ali Khan Khalil

Yeungnam University

SOUTH KOREA

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Jung-Eun Park

Staff Scientist

National Institutes of Health

UNITED STATES

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Frank Gonzalez

Research Interests

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Articles (16)

A liver phosphatase reprograms gut stem cells to drive hyperglycemia

FXR’s double life in bile ducts

Osteoarthritis treatment via GLP-1 mediated gut-joint axis by targeting intestinal FXR signaling

Adipose triglyceride lipase as a target for treatment of metabolic dysfunction-associated steatohepatitis: The role of hepatic and intestinal PPARα

HNF4A guides the MLL4 complex to establish and maintain H3K4me1 at gene regulatory elements

E2F3a activates Gadd45b gene expression through PPARα-mediated transcriptional regulation in hepatic cells

A gut microbiota-bile acid axis promotes intestinal homeostasis upon aspirin-mediated damage

Understanding Enterohepatic Bile Acid Pools and Their Impact on Intestinal Physiology

Structural Optimization and Anticancer Activity of Polo-like Kinase 1 (Plk1) Polo-Box Domain (PBD) Inhibitors and Their Prodrugs.

Hepatic fibrosis: Targeting peroxisome proliferator-activated receptor alpha from mechanism to medicines

Loss of toll-like receptor 5 potentiates spontaneous hepatocarcinogenesis in farnesoid X receptor–deficient mice

Parabacteroides distasonis ameliorates hepatic fibrosis potentially via modulating intestinal bile acid metabolism and hepatocyte pyroptosis in male mice.

Bile salt hydrolase in non-enterotoxigenic Bacteroides potentiates colorectal cancer.

Caffeic acid phenethyl ester suppresses intestinal FXR signaling and ameliorates nonalcoholic fatty liver disease by inhibiting bacterial bile salt hydrolase activity

Inhibition of estrogen sulfation by Xian-Ling-Gu-Bao capsule

Keratin 79 is a PPARA target that is highly expressed by liver damage

Collaborators (5)

Weiya Zhang

Xi Huang

Pamela Hoodless

Atif Ali Khan Khalil

Jung-Eun Park

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