Frank Hirth

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King’s College London

United Kingdom

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Recent Grants

Grant: Close

Molecular mechanisms of disease onset in TDP43 proteinopathies

Open Date: 2022-10-01

Close Date: 2025-09-01

Grant: Close

Mechanism of disease onset of C9 ALS/FTD

Open Date: 2017-10-01

Close Date: 2020-12-31

Grant: Close

Mechanisms of action initiation and maintenance

Open Date: 2016-01-01

Close Date: 2018-12-31

Grant: Close

Molecular mechanisms of TDP-43 mediated neurodegeneration

Open Date: 2014-06-30

Close Date: 2017-06-29

Grant: Close

Mechanisms of G4C2-derived dipeptide repeat protein toxicity in ALS

Open Date: 2014-02-01

Close Date: 2018-01-31

Articles (15)

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2025

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2025

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2022

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2021

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2021

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2021

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2020

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2020

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2020

Collaborators (7)

Manolis Fanto

Lecturer/Senior Lecturer

King’s College London

UNITED KINGDOM

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Erika Bereczki

Karolinska Institutet

SWEDEN

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Sean Sweeney

Professor

University of York

UNITED KINGDOM

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Alessio Vagnoni

Lecturer in Cellular Neuroscience

King’s College London

UNITED KINGDOM

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Joseph Bateman

King’s College London

UNITED KINGDOM

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Richard Bramwell Parsons

King’s College London

UNITED KINGDOM

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Lucy Granat

King's College London

UNITED KINGDOM

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Frank Hirth

Research Interests

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Recent Grants

Articles (15)

Brain anatomy of the Cambrian fossil Jianfengia multisegmentalis informs euarthropod phylogeny

Accumulation of TDP-43 causes karyopherin-α4 pathology that characterises amyotrophic lateral sclerosis.

Cambrian origin of the arachnid brain.

Yeast NDI1 reconfigures neuronal metabolism and prevents the unfolded protein response in mitochondrial complex I deficiency

Phylogenetic Tracing of Midbrain-Specific Regulatory Sequences Suggests Single Origin of Eubilaterian Brains

Yeast NDI1 reconfigures neuronal metabolism and prevents the unfolded protein response in mitochondrial complex I deficiency

Optogenetic cleavage of the Miro GTPase reveals the direct consequences of real-time loss of function in Drosophila.

Alpha-synucleinopathy reduces NMNAT3 protein levels and neurite formation that can be rescued by targeting the NAD+ pathway

Karyopherin abnormalities in neurodegenerative proteinopathies.

Presynaptic accumulation of α-synuclein causes synaptopathy and progressive neurodegeneration in Drosophila

Triad of TDP43 control in neurodegeneration: autoregulation, localization and aggregation.

Thermoresponsive motor behavior is mediated by ring neuron circuits in the central complex of Drosophila.

Ancestral regulatory mechanisms specify conserved midbrain circuitry in arthropods and vertebrates.

Immunostaining of the Embryonic and Larval Drosophila Brain

A miRNA screen procedure identifies garz as an essential factor in adult glia functions and validates Drosophila as a beneficial 3Rs model to study glial functions and GBF1 biology

Collaborators (7)

Manolis Fanto

Erika Bereczki

Sean Sweeney

Alessio Vagnoni

Joseph Bateman

Richard Bramwell Parsons

Lucy Granat

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