Frederic Darios

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Institut du Cerveau et de la Moelle Épinière

France

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Recent Grants

Grant: Close

Decreasing ganglioside synthesis as a therapy for hereditary spastic paraplegia

Open Date: 2019-10-01

Close Date: 2022-09-01

Grant: Close

Development of new therapy for rare motor neuron diseases

Open Date: 2018-11-01

Close Date: 2020-04-30

Grant: Close

Role of endoplasmic reticulum in neurodegeneration: physiopathology of a form of hereditary spastic paraplegia as a model

Open Date: 2013-04-01

Close Date: 2018-03-31

Articles (13)

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2025

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2024

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2024

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2022

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2021

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2020

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2020

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2020

Collaborators (7)

Manuela Basso

Assistant professor

ITALY

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Cyril Goizet

Professeur PU-PH

University of Bordeaux

FRANCE

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Giovanni Stevanin

Directeur d'Etudes Cumulant (Professor)

École Pratique des Hautes Études

FRANCE

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Alexandra Durr

Professor, MD, PhD,

Sorbonne Université

FRANCE

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Giorgio CASARI

Professor and Group Leader

Vita-Salute San Raffaele University

ITALY

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Janos Groh

University Hospital Würzburg

GERMANY

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Dennis Klein

GERMANY

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Frederic Darios

Research Interests

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Contact this professor

Recent Grants

Articles (13)

MAPT mutations in amyotrophic lateral sclerosis: clinical, neuropathological and functional insights

Decreasing ganglioside synthesis delays motor and cognitive symptom onset in Spg11 knockout mice

Clinically approved immunomodulators ameliorate behavioral changes in a mouse model of hereditary spastic paraplegia type 11

Spatacsin regulates directionality of lysosome trafficking by promoting the degradation of its partner AP5Z1

CNS-associated T-lymphocytes in a mouse model of Hereditary Spastic Paraplegia type 11 (SPG11) are therapeutic targets for established immunomodulators

Correction: Clinical, neuropathological, and genetic characterization of STUB1 variants in cerebellar ataxias: a frequent cause of predominant cognitive impairment

Implication of folate deficiency in CYP2U1 loss of function.

Genetics in hereditary spastic paraplegias: Essential but not enough.

Recent advances in understanding hereditary spastic paraplegias and emerging therapies.

Plasma neurofilament light chain predicts cerebellar atrophy and clinical progression in spinocerebellar ataxia.

Clinical, neuropathological, and genetic characterization of STUB1 variants in cerebellar ataxias: a frequent cause of predominant cognitive impairment.

Impairment of Lysosome Function and Autophagy in Rare Neurodegenerative Diseases

Lipids in the Physiopathology of Hereditary Spastic Paraplegias

Collaborators (7)

Manuela Basso

Cyril Goizet

Giovanni Stevanin

Alexandra Durr

Giorgio CASARI

Janos Groh

Dennis Klein

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