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Frederick Zeiler

Has grant

Professor

Karolinska Institutet

Sweden

Research Interests

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About

Frederick Zeiler is an Assistant Professor at Karolinska Institutet in Sweden, where he conducts research in the fields of cerebral physiology and traumatic neural injury. His recent work explores advanced sensor technologies for monitoring cerebral pressure-flow dynamics and the physiological implications of various treatments in acute brain injury. Key areas of his research include near-infrared spectroscopy and the effects of factors such as age and intracranial pressure on patient outcomes.

Recent Grants

Grant: Open

Subject-Specific Mammalian Neurovascular Physiologic Metrics Leveraging Electroencephalogram Entropy and Near Infrared Spectroscopy

Open Date: 2026-06-01

Close Date: 2032-06-01

Grant: Close

Integrated Data Science Platform for Complex Spatiotemporally Resolved Biomedical Applications

Open Date: 2026-03-01

Close Date: 2026-06-01

Grant: Open

Spatiotemporally Resolved Non-Invasive and Portable Whole Brain Cerebrovascular Imaging Using Functional Near Infrared Spectroscopy

Open Date: 2025-03-01

Close Date: 2027-02-01

Grant: Open

Continuously Updating Personalized Depth of Sedation Targeting Leveraging Autoregulation and Processed Electroencephalogram Signals

Open Date: 2025-01-01

Close Date: 2027-12-01

Grant: Open

Continuous Neuroprotection Based Personalized Depth of Sedation Targeting in Biomechanical Neural Injury

Open Date: 2024-12-01

Close Date: 2026-12-01

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Collaborators (27)

Andrew I.R Maas

Prof em

Antwerp University Hospital

BELGIUM

Frederick Zeiler

Research Interests

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About

Recent Grants

Articles (40)

The effectiveness of decompressive craniectomy size in traumatic brain injury; an international, observational, comparative effectiveness study

Association Between Individualized Intracranial Pressure Thresholds and Long-Term Outcomes in Moderate-to-Severe TBI: A CAHR-TBI Multicenter Study.

A Harmonised Protocol for the Use of PRx in Adult and Paediatric TBI Patients with ICP Monitoring: CLINICCA Workgroup Output.

Exploring the temporal statistical relationship between commercial cerebral near-infrared spectroscopy signals and intracranial pressure in traumatic brain injury.

Burr-Hole Drainage With or Without Irrigation for Chronic Subdural Hematoma, Postoperative Hematoma Volume, and Risk of Reoperation: A Post Hoc Analysis of the FINISH Trial.

Mendelian Randomization Analysis of the IL-1 Cytokine Family Proteins Identifies IL1RL1 as a Potential Causal Contributor to Traumatic Brain Injury Prognosis.

Comparative analysis of processed EEG indices and entropy-based metrics for assessing anesthetic depth: a scoping review - PRISMA-ScR.

Interpolation and Imputation Strategies for Missing Segments in Continuous Pressure-Flow Cerebral Bio-Signals: A Systematic Scoping Review

Management of Chronic Subdural Hematoma With Adjunctive Embolization of Middle Meningeal Artery: The EMMA-Can Randomized Clinical Trial.

Toward Causal Relationships of Intracranial Pressure, Cerebrovascular Reactivity, Interventions, and Outcome in Severe Traumatic Brain Injury: A CENTER-TBI High-Resolution Substudy.

A novel algorithm for the continuous determination of individualized intracranial pressure (iICP) thresholds using a multi-window weighted approach.

Detection of regional disparity in cerebrovascular reactivity using a custom whole brain functional near-infrared spectroscopy based mapping system: A prospective observational study.

Missing Data Gap Imputation Methods in Electroencephalogram (EEG) Signals: A Systematic Scoping Review

Algorithmic derivation of optimal CPP, MAP, and BIS targets from cerebrovascular reactivity indices: a systematic scoping review.

Evaluating the effect of point-sampling on univariate point and interval forecasting of cerebral physiologic signals using ARIMA modeling in acute traumatic neural injury

Practicalities of noninvasive neuromonitoring in intensive care

Rehabilitation and Outcomes in Patients after Traumatic Brain Injury Admitted to the Intensive Care Unit: Results from the CENTER-TBI Study.

ARIMA-based forecasting of cerebral physiologic signals in acute traumatic brain injury: a CAnadian high-resolution TBI (CAHR-TBI) cohort study

Influence of multiple trauma on the effect of transfusion strategies in patients with traumatic brain injury: a sub-study of the HEMOTION trial

Who Is Referred for Exercise Tolerance Testing Following a Concussion? An Evaluation of a Multidisciplinary Concussion Clinic

Impact of age and mean intracranial pressure on the morphology of intracranial pressure waveform and its association with mortality in traumatic brain injury.

Time-Domain Analysis of Low- and High-Frequency Near-Infrared Spectroscopy Sensor Technologies for Characterization of Cerebral Pressure–Flow and Oxygen Delivery Physiology: A Prospective Observational Study

Relationship Between RAP and Multi-Modal Cerebral Physiological Dynamics in Moderate/Severe Acute Traumatic Neural Injury: A CAHR-TBI Multivariate Analysis

Time-Series Autoregressive Models for Point and Interval Forecasting of Raw and Derived Commercial Near-Infrared Spectroscopy Measures: An Exploratory Cranial Trauma and Healthy Control Analysis

Where is our cerebral blood flow monitor?

Leveraging Function Intersectionality and Multi-Modal Cerebrovascular Reactivity Measures for the Derivation of Individualized Intracranial Pressure Thresholds in Acute Traumatic Neural Injury

Impact of Temporal Resolution on Autocorrelative Features of Cerebral Physiology from Invasive and Non-Invasive Sensors in Acute Traumatic Neural Injury: Insights from the CAHR-TBI Cohort

Commercial NIRS May Not Detect Hemispheric Regional Disparity in Continuously Measured COx/COx-a: An Exploratory Healthy and Cranial Trauma Time-Series Analysis

Relationship Between Signals from Cerebral near Infrared Spectroscopy Sensor Technology and Objectively Measured Cerebral Blood Volume: A Systematic Scoping Review

High-Frequency Analysis of the Cerebral Physiological Impact of Ketamine in Acute Traumatic Neural Injury.

Factorial validity and comparability of the six translations of the Rivermead Post-Concussion Symptoms Questionnaire translations: results from the CENTER-TBI study.

Comparative effectiveness of decompressive craniectomy versus craniotomy for traumatic acute subdural hematoma (CENTER-TBI): an observational cohort study.

Intracranial Pressure Monitoring and Treatment Thresholds in Acute Neural Injury: A Narrative Review of the Historical Achievements, Current State, and Future Perspectives.

Statistical properties of cerebral near infrared and intracranial pressure-based cerebrovascular reactivity metrics in moderate and severe neural injury: a machine learning and time-series analysis.

The impact of sedative and vasopressor agents on cerebrovascular reactivity in severe traumatic brain injury.

Regional disparity in continuously measured time-domain cerebrovascular reactivity indices: a scoping review of human literature

Non-Invasive Mapping of Cerebral Autoregulation Using Near-Infrared Spectroscopy: A Study Protocol

Discrete Fourier Transform Windowing Techniques for Cerebral Physiological Research in Neural Injury: A Practical Demonstration.

The effect of burst suppression on cerebral blood flow and autoregulation: a scoping review of the human and animal literature.

Temporal relationship between vasopressor and sedative administration and cerebrovascular response in traumatic brain injury: a time-series analysis

Collaborators (27)

Andrew I.R Maas

Arthur Ragauskas

Michael Verret

Thomas Van Essen

Agnieszka Kazimierska

Martin Ejler Fabricius

Rakibul Hasan

Logan Froese

Donald Griesdale

Marina Zeldovich

Mohammed Suheel Abdul Salam

Marcel J. H. Aries

Cecilia Åkerlund

Paul Dark

Agnieszka Uryga

Daniel Kondziella

Veronique De Keyser

Ari Ercole

Eric Thelin

Giuseppe Citerio

Magdalena Kasprowicz

Victoria McCredie

Johannes Gratz

Romit Samanta

Jussi P. Posti

D. James Cooper

Saulius Rocka

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