G Greg Wang

Duke University

United States

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Articles (16)

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2025

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2024

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2022

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2022

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2022

Collaborators (7)

shijie liu

Assistant Professor

Cincinnati Children's Hospital Medical Center

UNITED STATES

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Alexander Ruthenburg

Associate Professor

University of Chicago

UNITED STATES

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Chao Lu

Assistant Professor

Columbia University

UNITED STATES

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Benjamin Sabari

Assistant Professor

University of Texas Southwestern Medical Center

UNITED STATES

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Husnu Umit Kaniskan

Assistant Professor

Icahn School of Medicine at Mount Sinai

UNITED STATES

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Deyou Zheng

Assistant/Associate Professor/Professor

Albert Einstein College of Medicine

UNITED STATES

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Shenghui He

Assistant Professor

University of North Carolina at Chapel Hill

UNITED STATES

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G Greg Wang

Research Interests

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Articles (16)

The sotos syndrome gene Nsd1 safeguards developmental gene enhancers poised for transcription by maintaining the precise deposition of histone methylation

Pharmacologic degradation of WDR5 suppresses oncogenic activities of SS18::SSX and provides a therapeutic of synovial sarcoma

EZH2 PROTACs target EZH2- and FOXM1-associated oncogenic nodes, suppressing breast cancer cell growth

Structural basis for the H2AK119ub1-specific DNMT3A-nucleosome interaction

TAF2, within the TFIID complex, regulates the expression of a subset of protein-coding genes

Structure-guided functional suppression of AML-associated DNMT3A hotspot mutations

Charles David Allis (1951–2023)

Ribosomal protein RPL11 haploinsufficiency causes anemia in mice via activation of the RP-MDM2-p53 pathway

Through the lens of phase separation: intrinsically unstructured protein and chromatin looping

Onco-condensates: formation, multi-component organization, and biological functions

Dissecting and targeting noncanonical functions of EZH2 in multiple myeloma via an EZH2 degrader

Discovery of a First-in-Class Degrader for Nuclear Receptor Binding SET Domain Protein 2 (NSD2) and Ikaros/Aiolos

A cryptic transactivation domain of EZH2 binds AR and AR’s splice variant, promoting oncogene activation and tumorous transformation

Cell type-specific chromatin topology and gene regulation

A NSD3-targeted PROTAC suppresses NSD3 and cMyc oncogenic nodes in cancer cells

A PRC2-Kdm5b axis sustains tumorigenicity of acute myeloid leukemia

Collaborators (7)

shijie liu

Alexander Ruthenburg

Chao Lu

Benjamin Sabari

Husnu Umit Kaniskan

Deyou Zheng

Shenghui He

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