Gefei Chen

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Karolinska Institutet

Sweden

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Recent Grants

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Artificial spider silk preparation mediated by inteins

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Mechanism Study on Chaperone and Anti-Amyloid Activities of Bri2 BRICHOS–a New Potential Treatment for Alzheimer’s Disease

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Mechanism Studies on Chaperone and Anti-Amyloid Activities of Bri2 BRICHOS – a New Potential Treatment for Alzheimer’s Disease

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Mechanism study of Bri2 BRICHOS in inhibition of Alzheimer associated Aβ accumulation and as a general molecular chaperone

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National Scholarship for doctoral Students

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Articles (18)

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2025

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Simone Tambaro

Docent / Associate Professor

Karolinska Institutet

SWEDEN

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Tina Arndt

Karolinska Institutet

SWEDEN

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Henrik Biverstal

Karolinska Institutet

SWEDEN

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Cagla Sahin

Assistant Professor

University of Southern Denmark

DENMARK

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Rakesh Kumar

Karolinska Institutet

SWEDEN

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Marie Arsenian Henriksson

Karolinska Institutet

SWEDEN

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Axel Leppert

Karolinska Institutet

SWEDEN

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Daniel Ferreira

Karolinska Institutet

SWEDEN

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Gefei Chen

Research Interests

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Recent Grants

Articles (18)

Helicobacter pylori CagA protein is a potent and broad-spectrum amyloid inhibitor

Identification of potential aggregation hotspots on Aβ42 fibrils blocked by the anti-amyloid chaperone-like BRICHOS domain

Potential of molecular chaperones for treating Alzheimer’s disease

Robust Systemic and Mucosal Immune Responses to Coxsackievirus B3 Elicited by Spider Silk Protein Based Nanovaccines via Subcutaneous Immunization

Molecular basis for different substrate‐binding sites and chaperone functions of the BRICHOS domain

Eriodictyol downregulates UBA52 to promote autophagy and upregulates Nrf2/HO-1 to inhibit oxidative stress to ameliorate non-alcoholic fatty liver disease

Liquid-liquid crystalline phase separation of spider silk proteins

Intravenous chaperone treatment of late-stage Alzheimer´s disease (AD) mouse model affects amyloid plaque load, reactive gliosis and AD-related genes

A “grappling hook” interaction connects self-assembly and chaperone activity of Nucleophosmin 1

Liquid–Liquid Phase Separation Primes Spider Silk Proteins for Fiber Formation via a Conditional Sticker Domain

Short hydrophobic loop motifs in BRICHOS domains determine chaperone activity against amorphous protein aggregation but not against amyloid formation

A "spindle and thread" mechanism unblocks p53 translation by modulating N-terminal disorder

Amyloid Fibril Formation of Arctic Amyloid-β 1–42 Peptide is Efficiently Inhibited by the BRICHOS Domain

Customized Flagelliform Spidroins Form Spider Silk-like Fibers at pH 8.0 with Outstanding Tensile Strength

Abilities of the BRICHOS domain to prevent neurotoxicity and fibril formation are dependent on a highly conserved Asp residue

The synthesis and characterization of Bri2 BRICHOS coated magnetic particles and their application to protein fishing: Identification of novel binding proteins

Augmentation of Bri2 molecular chaperone activity against amyloid-β reduces neurotoxicity in mouse hippocampus in vitro

High intracellular stability of the spidroin N‐terminal domain in spite of abundant amyloidogenic segments revealed by in‐cell hydrogen/deuterium exchange mass spectrometry

Collaborators (13)

Per Nilsson

Jan Johansson

Arne Elofsson

Sonia Lain

Anna Rising

Simone Tambaro

Tina Arndt

Henrik Biverstal

Cagla Sahin

Rakesh Kumar

Marie Arsenian Henriksson

Axel Leppert

Daniel Ferreira

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