Geoffroy Laumet
Associate Professor
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About
Geoffroy Laumet is an Associate Professor at Michigan State University, USA. His research primarily focuses on the mechanisms of pain, particularly in relation to inflammatory processes, cancer pain, and the effects of various immunomodulatory interventions. Recent publications include studies on the role of mast cell-derived chymases in pain resolution and the communication between extracellular vesicles and neurons in HPV+ head and neck cancer. He is also investigating the potential repurposing of FDA-approved drugs for chronic pain relief.
Positions (1)
Geoffroy Laumet
Michigan State University
Join the Neuroimmunology of Pain Lab in the Department of Physiology and the Neuroscience Program at Michigan State University. The lab investigates how communications between sensory neurons and immune cells regulate the transition from acute to chronic pain, combining cutting-edge preclinical models with human translational samples to uncover novel therapeutic targets. Research Focus: Neuro-immune interactions in pain, immune cell regulation of pain resolution (monocytes, neutrophils, mast cells), integration of mouse genetic models with human samples, advanced approaches including single-cell RNA-seq, flow cytometry, imaging, and molecular biology. Responsibilities: Design and lead independent and collaborative projects, apply immunological, neuroscience, molecular, and genomic techniques, analyze and interpret complex datasets, contribute to manuscripts and conference presentations. Qualifications: PhD and strong background in neurobiology, immunology, or pain research. Evidence of scientific productivity in these fields. Experience with animal models and/or advanced molecular techniques preferred. Excellent communication and organizational skills. Highly motivated, independent, and collaborative mindset. Why Join Us? Dynamic and collaborative research environment, strong track record of scientific production, health insurance (including family members), access to state-of-the-art core facilities. Application: Send CV and brief statement of research interests to [email protected] or apply online via the MSU careers portal. For more information, visit the lab website.
Articles (7)
Year:
2025
Year:
2024
Severe pain is often experienced by patients with head and neck cancer and is associated with a poor prognosis. Despite its frequency and severity, current treatments fail to adequately control cancer-associated pain because of our lack of mechanistic understanding. Although recent works have shed some light of the biology underlying pain in HPV-negative oral cancers, the mechanisms mediating pain in HPV+ cancers remain unknown. Cancer-derived small extracellular vesicles (cancer-sEVs) are well positioned to function as mediators of communication between cancer cells and neurons. Inhibition of cancer-sEV release attenuated pain in tumor-bearing mice. Injection of purified cancer-sEVs is sufficient to induce pain hypersensitivity in naive mice that is prevented by QX-314 treatment and in Trpv1 −/− mice. Cancer-sEVs triggered calcium influx in nociceptors, and inhibition or ablation of nociceptors protects against cancer pain. Interrogation of published sequencing data of human sensory neurons exposed to human cancer-sEVs suggested a stimulation of protein translation in neurons. Induction of translation by cancer-sEVs was validated in our mouse model, and its inhibition alleviated cancer pain in mice. In summary, our work reveals that HPV+ head and neck squamous cell carcinoma–derived sEVs alter TRPV1+ neurons by promoting nascent translation to mediate cancer pain and identified several promising therapeutic targets to interfere with this pathway.
Year:
2023
Year:
2022
Year:
2022
Year:
2021
Year:
2020
Collaborators (5)
Nathan Tykocki
Assistant Professor
Michigan State University
Victoria Gómez Murcia
Profesor Ayudante Doctor (Assistant Professor)
Universidad de Murcia
Corinne ABBADIE
Professor
Université de Lille
Albert DAHDAH
Karolinska Institutet
Christian S Stohler
Professor and Dean - Sr. VP, CUIMC
Columbia University
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