Gergely Lukacs

Professor

McGill University Faculty of Medicine

Canada

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Professor Gergely Lukacs is a faculty member at McGill University Faculty of Medicine in Canada. His research focuses on the molecular dynamics of the CFTR protein, particularly in relation to its folding, allosteric interactions, and therapeutic interventions in obstructive airway diseases. Recent articles by Professor Lukacs highlight advancements in precision medicine and the development of novel drug compounds aimed at enhancing CFTR functionality.

Articles (10)

Year:

2023

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2022

Year:

2022

Year:

2021

Year:

2021

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2021

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2020

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2020

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2020

Year:

2020

Collaborators (8)

Michaela Matthey

Ruhr-Universität Bochum Medizinische Fakultät

GERMANY

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Nicola J Smith

Senior Lecturer

UNSW Sydney

AUSTRALIA

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Hedvig Tordai

Semmelweis University

HUNGARY

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Damien RAMEL

FRANCE

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Wito Richter

University of South Alabama College of Medicine

UNITED STATES

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Daniela Wenzel

Ruhr-Universität Bochum

GERMANY

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Alessandra Ghigo

Assistant Professor

University of Turin

ITALY

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Rosa Angela Cardone

University of Bari

ITALY

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Gergely Lukacs

Research Interests

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About

Articles (10)

Folding correctors can restore CFTR posttranslational folding landscape by allosteric domain-domain coupling.

A PI3Kγ mimetic peptide triggers CFTR gating, bronchodilation, and reduced inflammation in obstructive airway diseases.

Nanomechanics combined with HDX reveals allosteric drug binding sites of CFTR NBD1

A precision medicine approach to optimize modulator therapy for rare cftr folding mutants

Control of membrane protein homeostasis by a chaperone-like glial cell adhesion molecule at multiple subcellular locations

Elexacaftor co-potentiates the activity of F508del and gating mutants of CFTR

High-throughput phenotyping of heteromeric human ether-à-go-go-related gene potassium channel variants can discriminate pathogenic from rare benign variants

Allosteric folding correction of F508del and rare CFTR mutants by elexacaftor-tezacaftor-ivacaftor (Trikafta) combination

Mutation-specific dual potentiators maximize rescue of CFTR gating mutants

Selective Binding of HSC70 and its Co-Chaperones to Structural Hotspots on CFTR

Collaborators (8)

Michaela Matthey

Nicola J Smith

Hedvig Tordai

Damien RAMEL

Wito Richter

Daniela Wenzel

Alessandra Ghigo

Rosa Angela Cardone

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