Gerhard Wolber

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Freie Universität Berlin

Germany

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About

Gerhard Wolber is a Professor at Freie Universität Berlin, Germany. His research areas include the development of pharmacological agents for immune response modulation and the optimization of small molecules targeting various receptors. Recent articles focus on TLR8 antagonists, CYP19A1 inhibitors, and cellular target engagement in immune checkpoints. His work contributes significantly to the fields of medicinal chemistry and pharmacology.

Recent Grants

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Safer analgesics by modulation of the kappa-opioid receptor

Open Date: 2020-01-01

Close Date:

Grant: Close

Molecular interaction between ribosome-inactivating proteins and triterpene saponins

Open Date: 2019-01-01

Close Date:

Grant: Close

Targeting the first barrier of immune response: Rational design of small molecule Toll-like receptor modulators

Open Date: 2016-01-01

Close Date:

Grant: Close

Design of Novel Arginase 1 Inhibitors for Re-Establishing Anti-Tumor Immune Response

Open Date: 2013-01-01

Close Date: 2017-12-31

Grant: Close

Discovery of TLR2 antagonists as anti-inflammatory drugs

Open Date: 2010-08-15

Close Date: 2014-08-14

Articles (28)

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2022

Collaborators (8)

Moustafa Gabr

Assistant Professor

Weill Cornell Medicine

UNITED STATES

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Maria Kristina Parr

GERMANY

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Gerald W. Zamponi

University of Calgary

CANADA

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Mariana Spetea

University of Innsbruck

AUSTRIA

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Helmut Schmidhammer

Professor

University of Innsbruck

AUSTRIA

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Temilolu Idowu

The University of British Columbia

CANADA

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Valerij Talagayev

Freie Universität Berlin

GERMANY

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Kai Ludwig

Freie Universität Berlin

GERMANY

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Gerhard Wolber

Research Interests

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About

Recent Grants

Articles (28)

Agonists and Antagonists Show Different Unbinding Paths from the TLR8 Receptor

Optimization of 6-(trifluoromethyl)pyrimidine derivatives as TLR8 antagonists

Effects of the Dietary Supplement 5α‐Hydroxy‐Laxogenin in the Orchiectomized Rat Model

Integrated Virtual Screening Approach Identifies New CYP19A1 Inhibitors

Biginelli dihydropyrimidines and their acetylated derivatives as L‐/T‐type calcium channel blockers: Synthesis, enantioseparation, and molecular modeling studies

Discovery of Novel Isoxazole-Based Small-Molecule Toll-Like Receptor 8 Antagonists

Derivatization of Microcystins Can Increase Target Inhibition while Reducing Cellular Uptake

Synthesis, molecular modeling, DFT studies, and EPR analysis of 1,4-dihydropyridines as potential calcium channel blockers

Discovery of Novel, Selective, and Nonbasic Agonists for the Kappa-Opioid Receptor Determined by Salvinorin A-Based Virtual Screening

Correction to: Targeted small molecule inhibitors blocking the cytolytic effects of pneumolysin and homologous toxins (Nature Communications, (2024), 15, 1, (3537), 10.1038/s41467-024-47741-3)

Disrupting TSLP–TSLP receptor interactions via putative small molecule inhibitors yields a novel and efficient treatment option for atopic diseases

Disrupting TSLP-TSLP receptor interactions via putative small molecule inhibitors yields a novel and efficient treatment option for atopic diseases

Identification of New Substrates and Inhibitors of Human CYP2A7

Identification of New Substrates and Inhibitors of Human CYP2A7

Synthesis, molecular modeling, DFT studies, and EPR analysis of 1,4-dihydropyridines as potential calcium channel blockers

Targeted small molecule inhibitors blocking the cytolytic effects of pneumolysin and homologous toxins

Targeted small molecule inhibitors blocking the cytolytic effects of pneumolysin and homologous toxins

From Virtual Screens to Cellular Target Engagement: New Small Molecule Ligands for the Immune Checkpoint LAG-3

Discovery of Small-Molecule TIM-3 Inhibitors for Acute Myeloid Leukemia Using Pharmacophore-Based Virtual Screening

Solving an Old Puzzle: Elucidation and Evaluation of the Binding Mode of Salvinorin A at the Kappa Opioid Receptor

Mechanistic Characterization of the Pharmacological Profile of HS-731, a Peripherally Acting Opioid Analgesic, at the &micro;-, &delta;-, &kappa;-Opioid and Nociceptin Receptors

Experimental and Computational Studies on the Biotransformation of Pseudopyronines with Human Cytochrome P450 CYP4F2

Changes in Alprazolam Metabolism by CYP3A43 Mutants

A Combined Bayesian and Similarity-Based Approach for Predicting E. coli Biofilm Inhibition by Phenolic Natural Compounds

Mind the Gap—Deciphering GPCR Pharmacology Using 3D Pharmacophores and Artificial Intelligence

Complete Reaction Phenotyping of Propranolol and 4-Hydroxypropranolol with the 19 Enzymes of the Human UGT1 and UGT2 Families

In Vitro, In Vivo and In Silico Characterization of a Novel Kappa-Opioid Receptor Antagonist

Validated Capillary Zone Electrophoresis Method for Impurity Profiling and Determination of NiII(3-OMe-Salophene)

Collaborators (8)

Moustafa Gabr

Maria Kristina Parr

Gerald W. Zamponi

Mariana Spetea

Helmut Schmidhammer

Temilolu Idowu

Valerij Talagayev

Kai Ludwig

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Mechanistic Characterization of the Pharmacological Profile of HS-731, a Peripherally Acting Opioid Analgesic, at the µ-, δ-, κ-Opioid and Nociceptin Receptors