Gert Matthijs

KU Leuven is inviting applications for a PhD researcher position within the ERDERA RADICAL-CDG project, focusing on developing therapeutic options for dolichol synthesis defects—a rare congenital glycosylation disorder (CDG). The research will be conducted at the Centre for Human Genetics, KU Leuven, as part of a pan-European collaboration involving 18 partners across 8 countries. The project is funded by the European Rare Diseases Research Alliance (ERDERA). The successful candidate will engage in molecular, cellular, and translational research, aiming to move discoveries from cell models to animal models and ultimately to patient applications. Key responsibilities include applying molecular biology techniques (DNA, RNA, protein) across various cell systems, generating cellular models using CRISPR/Cas9 gene-editing, developing and optimizing liposomal formulations, and performing LC-MS-based lipid/metabolomics analyses. The candidate will also present findings at lab meetings and international conferences, supervise bachelor/master students, and collaborate with international teams within the RADICAL-CDG consortium. Applicants should have a Master’s degree in Biomedical Sciences, Medicine, Pharmacy, Biochemistry, Bioengineering, Biology, or a related field, with a strong academic record (distinction or above). Prior experience with molecular biology techniques and cell culture, excellent English communication skills, and motivation for a 4-year PhD are essential. The ability to work both independently and collaboratively is required. The position offers a full-time contract (initially 1 year, extendable to 4 years upon positive evaluation), remuneration according to the KU Leuven PhD salary scale, travel reimbursement, access to state-of-the-art research infrastructure, KU Leuven training programs, and opportunities for international collaboration and conferences. Application deadline is 21 April 2026. For more information or to apply, visit the KU Leuven job portal or contact Prof. dr. Gert Matthijs ([email protected]) or Prof. dr. Matthew Wilson ([email protected]).