Giacomo Paonessa

Head of Infectious Disease Unit

Italy

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About

Dr. Giacomo Paonessa is the Head of the Infectious Disease Unit at IRBM S.p.A. in Italy. His research focuses on the discovery and optimization of treatments for parasitic infections, with recent articles highlighting the development of inhibitors for Zika virus and Trypanosoma species. Dr. Paonessa's work also includes the identification of new plant species contributing to medicinal chemistry.

Articles (6)

Year:

2023

Year:

2022

Year:

2022

Year:

2020

Year:

2020

Year:

2020

Collaborators (1)

Mario Martínez-Azorín

Universidad de Alicante

SPAIN

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Giacomo Paonessa

Research Interests

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Articles (6)

Trimelopter cordifolium (Hyacinthaceae subfam. Ornithogaloideae), a new species from South Africa

Gametocyte-specific and all-blood-stage transmission-blocking chemotypes discovered from high throughput screening on Plasmodium falciparum gametocytes.

SAR evolution towards potent C-terminal carboxamide peptide inhibitors of Zika virus NS2B-NS3 protease.

Spiro-containing derivatives show antiparasitic activity against Trypanosoma brucei through inhibition of the trypanothione reductase enzyme.

Optimization of 2-(1H-imidazo-2-yl)piperazines series of Trypanosoma brucei growth inhibitors as potential treatment for the second stage of HAT.

Discovery of 4-((1-(1H-imidazol-2-yl)alkoxy)methyl)pyridines as a new class of Trypanosoma cruzi growth inhibitors.

Collaborators (1)

Mario Martínez-Azorín

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