Giulia Nardi

Key Points Historically percutaneous coronary interventions (PCI) of severely calcified lesions is associated with high rate of periprocedural complications and poor long‐term outcomes. Available data from controlled prospective registries reported promising safety and efficacy results of intravascular lithotripsy (IVL) but were limited to restricted inclusion criteria. This multicenter IVL registry in all‐comer patients including very long lesions, S‐T segment elevation myoìcardial infarction, chronic total occlsusion and left main PCI confirmed high procedural success, low rate of periprocedural complications and good long‐term outcome.