Gordon Buchanan

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Associate Professor

University of Iowa Healthcare

United States

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Gordon Buchanan is an Associate Professor at the University of Iowa Healthcare, USA. His research focuses on the mechanisms underlying seizure activity, cellular responses to brain injury, and the role of serotonergic and purinergic signaling in epilepsy. Recent publications include studies on unique enzymatic roles related to SYNGAP1 and novel therapies for seizure cessation using optogenetics.

Recent Grants

Grant: Open

Serotonergic circuit mechanisms in postictal recovery and arousal

Open Date: 2022-12-01

Close Date: 2027-11-30

Grant: Close

Nighttime mechanisms for SUDEP

Open Date: 2022-11-01

Close Date: 2024-10-31

Grant: Close

Sleep state-dependent mechanisms of seizure-induced death

Open Date: 2016-04-01

Close Date: 2021-03-31

Grant: Close

Role of vigilance state and circadian phase in seizure-related death

Open Date: 2013-10-01

Close Date: 2015-07-31

Grant: Close

Serotonin neurons in arousal, epilepsy and SUDEP

Open Date: 2011-07-01

Close Date: 2017-06-30

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2021

Collaborators (1)

Joel Geerling

Assistant Professor

Iowa State University

UNITED STATES

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Gordon Buchanan

Research Interests

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About

Recent Grants

Articles (23)

Playing Multiple Parts: Unique Enzymatic and Structural Roles Orchestrated by SYNGAP1

Serotonin neurons are necessary for tonic sodium intake inhibition

Lighting the Way to Seizure Cessation: Transcranial Optogenetic Therapies to Stop Seizures in Mouse Models

MK-212 precipitates seizure-induced death in amygdala-kindled mice via a non-5-HT2C receptor-mediated mechanism

Seizure‐related death exhibits a circadian rhythm independent of seizure timing or sleep in a mouse model of Dravet syndrome

Who's Down With UDP?—Not Epilepsy; Purinergic Microglial Ca 2+ Signaling Mediates Epileptogenesis

Stopping runaway seizures with a chill pill

Leigh has no Brakes: Impaired Inhibition in a Mouse Model of Leigh Syndrome Leads to Enhanced Seizure Sensitivity

Effect of adenosinergic manipulations on amygdala‐kindled seizures in mice: Implications for sudden unexpected death in epilepsy

Peri-ictal activation of dorsomedial dorsal raphe serotonin neurons reduces mortality associated with maximal electroshock seizures

Determining the Spread: Potential Biomarkers and Treatment for Seizure-Induced-Spreading Depolarization in a Mouse Model of Genetic Epilepsy

Assessment of Cellular End of Life Management in Acute Brain Injury: Clearing Dying Cells After Injury

Slow Down and Seize: Seizures Triggered by Slow Wave Oscillations in a GABAergic Model of Dravet Syndrome

Under New Management: Transplanted GABAergic Progenitors Control Adult Neurogenesis

Selective Serotonin Reuptake Inhibitors and 5-HT2 Receptor Agonists Have Distinct, Sleep-state Dependent Effects on Postictal Breathing in Amygdala Kindled Mice

ABCDEF…SUDEP: Action Potential Barrage in (Superior) Colliculus Causes (Spreading) Depolarization Leading to Epilepsy Fatality

Acute hydrogen sulfide-induced neurochemical and morphological changes in the brainstem

Revoking the Seize Order: Preventing Spontaneous Seizures With AAV in a CLN2 Mouse Model

Chronobiology of epilepsy and sudden unexpected death in epilepsy.

Not All Paths are Equal: Stimulating Specific Cerebellar Outputs Inhibits Hippocampal Seizures

The role of sleep state and time of day in modulating breathing in epilepsy: implications for sudden unexpected death in epilepsy.

Light, Kindling, Action! Brain-Wide Circuit Changes After Optogenetic Hippocampal Kindling Revealed by Functional Magnetic Resonance Imaging

Tuning the Wave: Controlling Spreading Depolarization with Activation/Inactivation of Kv7.2

Collaborators (1)

Joel Geerling

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