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Graham Chakafana

Assistant Professor

Hampton University

United States

Research Interests

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Graham Chakafana is an Assistant Professor at Hampton University in the United States. His research primarily focuses on the role of molecular chaperones, particularly in relation to the heat shock proteins of Plasmodium falciparum , and their implications in human diseases such as peripartum cardiomyopathy. Recent publications highlight his work on client selection and recognition mechanisms involving Hsp70 and Hsp110 chaperones, as well as insights into the genetic aspects of cardiovascular conditions.

Articles (16)

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Collaborators (4)

Xolani Henry Makhoba

Senior Lecturer

University of South Africa

SOUTH AFRICA

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Peter Myler

Professor

University of Washington

UNITED STATES

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Oluwatoyin Asojo

Professor

Dartmouth College

UNITED STATES

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Tawanda Zininga

Senior Lecturer

Stellenbosch University

SOUTH AFRICA

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Graham Chakafana

Research Interests

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About

Articles (16)

Clinical characteristics, echocardiographic findings, six-month outcomes in Ugandan women with peripartum cardiomyopathy

Structure of Plasmodium vivaxN-myristoyltransferase with inhibitor IMP-1088: Exploring an NMT inhibitor for antimalarial therapy

Advances in biomarker discovery for peripartum cardiomyopathy: current status and future directions

Relationship between baseline right ventricular systolic function and left ventricular recovery at six-months of follow up among women with peripartum cardiomyopathy in Uganda

Editorial: Molecular chaperones and polyamines in disease

Biochemistry of Heat Shock Proteins From Human Intracellular Protozoan Parasites as Diagnostic and Therapeutic Biomarkers

Swapping the linkers of canonical Hsp70 and Hsp110 chaperones compromises both self-association and client selection

Insertion of GGMP repeat residues of Plasmodium falciparum Hsp70-1 in the lid of DnaK adversely impacts client recognition.

Proteomic Profiling in Patients With Peripartum Cardiomyopathy: A Biomarker Study of the ESC EORP PPCM Registry.

Editorial: Molecular chaperones and human disease.

Heat Shock Proteins: Potential Modulators and Candidate Biomarkers of Peripartum Cardiomyopathy.

Supporting data on characterisation of linker switch mutants of <i>Plasmodium falciparum</i> heat shock protein 110 and canonical Hsp70.

WHF Position Statement on COVID Vaccination.

Characterisation of a unique linker segment of the Plasmodium falciparum cytosol localised Hsp110 chaperone.

Mutation of GGMP Repeat Segments of <i>Plasmodium falciparum</i> Hsp70-1 Compromises Chaperone Function and Hop Co-Chaperone Binding.

Genetics of Peripartum Cardiomyopathy: Current Knowledge, Future Directions and Clinical Implications.

Collaborators (4)

Xolani Henry Makhoba

Peter Myler

Oluwatoyin Asojo

Tawanda Zininga

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