Gregory Thatcher

Professor

University of Arizona

United States

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Gregory Thatcher is a Professor at the University of Arizona, USA. His research focuses on drug discovery and development, with a particular interest in thioredoxin reductases, bromodomains, and mechanisms of viral entry inhibitors. Recent articles highlight his work on novel therapeutic compounds for conditions such as Alzheimer's disease, type 2 diabetes, and cancer. He continues to explore innovative approaches to address complex biological challenges through metabolomic analysis and structural optimization.

Articles (10)

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2024

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2024

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2021

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2021

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2021

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2021

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2020

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2020

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2020

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2020

Collaborators (2)

Francesco ANGELUCCI

Full Professor of Biochemistry

University of L'Aquila

ITALY

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Md. Wasim Khan

Assistant Professor

University of Chicago

UNITED STATES

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Gregory Thatcher

Research Interests

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Articles (10)

The “Doorstop Pocket” In Thioredoxin Reductases─An Unexpected Druggable Regulator of the Catalytic Machinery

Structure-Guided Design and Synthesis of Pyridinone-Based Selective Bromodomain and Extra-Terminal Domain (BET)-First Bromodomain (BD1) Inhibitors

Metabolomic analysis of a selective ABCA1 inducer in obesogenic challenge provides a rationale for therapeutic development

Discovery of Nonlipogenic ABCA1 Inducing Compounds with Potential in Alzheimer’s Disease and Type 2 Diabetes

Extending the Calpain–Cathepsin Hypothesis to the Neurovasculature: Protection of Brain Endothelial Cells and Mice from Neurotrauma

Evidence for distinct mechanisms of small molecule inhibitors of filovirus entry

Discovery and Structural Optimization of 4-(Aminomethyl)benzamides as Potent Entry Inhibitors of Ebola and Marburg Virus Infections

Optimization of 4-Aminopiperidines as Inhibitors of Influenza A Viral Entry That Are Synergistic with Oseltamivir

Characterization of Lead Compounds Targeting the Selenoprotein Thioredoxin Glutathione Reductase for Treatment of Schistosomiasis

G1T48, an oral selective estrogen receptor degrader, and the CDK4/6 inhibitor lerociclib inhibit tumor growth in animal models of endocrine-resistant breast cancer.

Collaborators (2)

Francesco ANGELUCCI

Md. Wasim Khan

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