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Guojun Bu

Has grant

Chair Professor

The Hong Kong University of Science and Technology

China

Research Interests

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Professors in Cell Biology

Recent Grants

Grant: Open

Effects of peripheral apoE2 on Alzheimer’s disease pathology and pathways

Open Date: 2024-07-01

Close Date: 2027-06-30

Grant: Close

Partnership with Molecular Neurodegeneration Open Access Journal

Open Date: 2010-07-01

Close Date: 2015-06-30

Grant: Close

LRP1 and Insulin Receptor Signaling in AD

Open Date: 2010-04-01

Close Date: 2013-03-31

Grant: Close

Modulation of APP Trafficking and Abeta Production

Open Date: 2006-04-01

Close Date: 2008-03-31

Articles (20)

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Collaborators (8)

Na Zhao

Associate Professor

Mayo Clinic Florida

UNITED STATES

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Elizabeth Bradshaw

Assistant Professor

UCM

UNITED STATES

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David Knopman

Professor

Mayo Clinic Rochester

UNITED STATES

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Yann Le Guen

Stanford University

UNITED STATES

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Ioana - Emilia Mosneag

The University of Manchester

UNITED KINGDOM

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Fabienne Fiesel

Assistant Professor

Mayo Clinic

UNITED STATES

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Chia-Chen Liu

Assistant Professor

Mayo Clinic Research Florida

UNITED STATES

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Shunsuke Koga

Hospital of the University of Pennsylvania

UNITED STATES

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Guojun Bu

Research Interests

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Recent Grants

Articles (20)

Alzheimer disease protection from the periphery

Flipping APOE to reverse Alzheimer’s disease traits

Brain-wide microglia replacement using a non-conditioning strategy ameliorates pathology in mouse models of neurological disorders

Impact of <i>APOE</i> on amyloid and tau accumulation in argyrophilic grain disease and Alzheimer's disease

LRP1 in vascular mural cells modulates cerebrovascular integrity and function in the presence of APOE4.

Genome-wide association study of brain biochemical phenotypes reveals distinct genetic architecture of Alzheimer's disease related proteins.

An assay to evaluate the capacity of cholesterol acceptors using BODIPY-cholesterol in cells.

Alpha‐synuclein‐associated changes in PINK1‐PRKN‐mediated mitophagy are disease context dependent

A TREM2 antibody energizes microglia

Association of African Ancestry-Specific APOE Missense Variant R145C With Risk of Alzheimer Disease.

<i>APOE</i> and immunity: Research highlights

ABCA7 deficiency causes neuronal dysregulation by altering mitochondrial lipid metabolism

APOE deficiency impacts neural differentiation and cholesterol biosynthesis in human iPSC-derived cerebral organoids

APOE genotypes modify the obesity paradox in dementia

Cell-autonomous effects of APOE4 in restricting microglial response in brain homeostasis and Alzheimer’s disease

Microglial repopulation reverses cognitive and synaptic deficits in an Alzheimer's disease model by restoring BDNF signaling

Pathophysiology and probable etiology of cerebral small vessel disease in vascular dementia and Alzheimer’s disease

Pushing the boundaries of brain organoids to study Alzheimer's disease

Author Correction: Performance of plasma phosphorylated tau 181 and 217 in the community

APOE2 Exacerbates TDP-43 Related Toxicity in the Absence of Alzheimer Pathology.

Collaborators (8)

Na Zhao

Elizabeth Bradshaw

David Knopman

Yann Le Guen

Ioana - Emilia Mosneag

Fabienne Fiesel

Chia-Chen Liu

Shunsuke Koga

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