Gustavo Seabra

Research Associate Professor

University of Florida

United States

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Gustavo Seabra is a Research Associate Professor at the University of Florida, USA. His research focuses on synthetic lethal inhibitors in cancer therapy, pharmaceutical design utilizing machine learning, and the biochemical characterization of natural products. Recent publications include studies on PRMT5 interactions in cancer cells, novel drug discovery methods, and the biological properties of marine compounds.

Articles (17)

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2025

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2025

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2025

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2024

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2024

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2023

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2022

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2021

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2021

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2021

Collaborators (6)

Ruogu Fang

Associate Professor

University of Florida

UNITED STATES

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Hendrik Luesch

University of Florida

UNITED STATES

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Taimour Langaee

University of Florida

UNITED STATES

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Jiang Bian

Associate Professor

University of Florida

UNITED STATES

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Larisa Cavallari

Professor

University of Florida

UNITED STATES

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Jason Brant

Research Assistant Professor

University of Florida

UNITED STATES

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Gustavo Seabra

Research Interests

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Articles (17)

Discovery and Mechanism of 16–19F, a Novel Synthetic Lethal Inhibitor of the PRMT5•MTA Complex in MTAP-Deleted Cancer Cells

Virtual High-Throughput Screening of Ligands for Disrupting PRMT5/pICLn Interaction in Prostate Cancer Cells

Discovery of PRMT5 N-Terminal TIM Barrel Ligands from Machine-Learning-Based Virtual Screening

Grassystatin G, a new cathepsin D inhibitor from marine cyanobacteria: discovery, synthesis, and biological characterization

Assessing the Performance of In silico Tools and Molecular Dynamics Simulations for Predicting Pharmacogenetic Variant Impact

Design Principle of Heparanase Inhibitors: A Combined In Vitro and In Silico Study

Morphological profiling for drug discovery in the era of deep learning

Chloroformate-Mediated Ring Cleavage of Indole Alkaloids Leads to Re-engineered Antiplasmodial Agents

Characterization of a Dual Function Peptide Cyclase in Graspetide Biosynthesis

Carbohydrate-Binding Mechanism of the Coagulant Lectin from Moringa oleifera Seeds (cMoL) Is Related to the Dimeric Protein Structure

Molecular Recognition Study toward the Mitochondrial Electron Transport Chain Inhibitor Mubritinib and Human Serum Albumin

Chlorinated Enyne Fatty Acid Amides from a Marine Cyanobacterium: Discovery of Taveuniamides L-M and Pharmacological Characterization of Taveuniamide F as a GPCR Antagonist with CNR1 Selectivity

Probing a distinct druggable tubulin binding site with gatorbulins 1–7, their metabolic and physicochemical properties, and pharmacological consequences

Diversity and Chemical Library Networks of Large Data Sets

Binding Mechanism between Acetylcholinesterase and Drugs Pazopanib and Lapatinib: Biochemical and Biophysical Studies

Bifunctional Doscadenamides Activate Quorum Sensing in Gram-Negative Bacteria and Synergize with TRAIL to Induce Apoptosis in Cancer Cells

Effects of pyriproxyfen on zebrafish brain mitochondria and acetylcholinesterase

Collaborators (6)

Ruogu Fang

Hendrik Luesch

Taimour Langaee

Jiang Bian

Larisa Cavallari

Jason Brant

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