Guy C. Brown

United Kingdom

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Articles (8)

Year:

2022

Year:

2022

Year:

2021

Year:

2021

Year:

2021

Year:

2021

Year:

2020

Year:

2020

Collaborators (4)

Mar Puigdellívol Cañadell

Assistant Professor

University of Barcelona

SPAIN

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Harald Neumann

Professor of Neural Regeneration

University of Bonn

GERMANY

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Jennifer Pocock

University College London

UNITED KINGDOM

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Christine Klaus

University of Bonn

GERMANY

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Guy C. Brown

Research Interests

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Articles (8)

Alzheimer's disease-associated R47H TREM2 increases, but wild-type TREM2 decreases, microglial phagocytosis of synaptosomes and neuronal loss.

Knockout of the P2Y<sub>6</sub> Receptor Prevents Peri-Infarct Neuronal Loss after Transient, Focal Ischemia in Mouse Brain

Sialylation acts as a checkpoint for innate immune responses in the central nervous system

Microglial phagocytosis of neurons in neurodegeneration, and its regulation

CD33M inhibits microglial phagocytosis, migration and proliferation, but the Alzheimer's disease-protective variant CD33m stimulates phagocytosis and proliferation, and inhibits adhesion.

I'm infected, eat me! Innate immunity mediated by live, infected cells signalling to be phagocytosed.

Sialylation and Galectin-3 in Microglia-Mediated Neuroinflammation and Neurodegeneration

Lipopolysaccharide activates microglia via neuraminidase 1 desialylation of Toll-like Receptor 4.

Collaborators (4)

Mar Puigdellívol Cañadell

Harald Neumann

Jennifer Pocock

Christine Klaus

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