Hany A. Omar

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Articles (20)

Hepatocellular carcinoma (HCC) significantly contributes to cancer‐related mortality due to the limited response of HCC to current anticancer therapies, thereby necessitating more effective treatment approaches. Energy restriction mimetic agents (ERMAs) have emerged as potential therapies in targeting the Warburg effect, a unique metabolic process in cancer cells. However, ERMAs exhibit limited efficacy when used as monotherapy. Additionally, ERMAs have been found to induce autophagy in cancer cells. The role of autophagy in cancer survival remains a subject of debate. Thus, it is crucial to ascertain whether ERMA‐induced autophagy is a mechanism for cell survival or cell death in HCC. Our study aims to investigate the effect of autophagy inhibition on the survival of HCC cells treated with ERMAs while also examining the potential of combining an autophagy inhibitor such as spautin‐1 with ERMAs to enhance HCC cell death. Our results suggest a cytoprotective role for ERMA‐induced autophagy in HCC cells, as combining the autophagy inhibitor spautin‐1 with ERMAs effectively suppressed ERMA‐induced autophagy and synergistically enhanced their antitumor activity. The treatment combination promoted HCC death through apoptosis, cell cycle arrest, and inhibition of AKT and ERK activation, which are known to play a key role in cellular proliferation. Collectively, our findings highlight a potential strategy to combat HCC by combining energy restriction with autophagy inhibition.

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2021

Collaborators (80)

Patricia Cullen

UNSW Sydney

AUSTRALIA
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Cijo George Vazhappilly

-

UNITED ARAB EMIRATES
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Hanan S Anbar

-

UNITED ARAB EMIRATES
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Tomasz Miazgowski

Pomeranian Medical University

POLAND
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Christine Mpundu-Kaambwa

Flinders University

AUSTRALIA
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Benn Sartorius

Associate Professor/Principal Research Fellow

University of Queensland

AUSTRALIA
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Sumaira Mubarik

Assistant Professor

University of Groningen

NETHERLANDS
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Yafei Si

University of Melbourne

AUSTRALIA
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Alberto Freitas

Assistant Professor

Faculty of Medicine of the University of Porto

PORTUGAL
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Derek Chew

Assistant Professor

University of Calgary

CANADA
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Mohammed Elmowafy

-

SAUDI ARABIA
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Sheng-Chia Chung

University College London

UNITED KINGDOM
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Lennart Reifels

University of Melbourne

AUSTRALIA
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Moien AB Khan

-

UNITED ARAB EMIRATES
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Ameeduzzafar Zafar

-

SAUDI ARABIA
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Jerry John Nutor

University of California, San Francisco

UNITED STATES
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Nuno Taveira

Full Professor

Instituto Universitário de Ciências da Saúde

PORTUGAL
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Yannick Béjot

Professor of Neurology

University of Burgundy

FRANCE
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Luís Belo

Assistant Professor with Habilitation

Faculty of Pharmacy, University of Lisbon

PORTUGAL
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John McGrath

Aarhus University

DENMARK
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Serge Resnikoff

Visiting Professor

University of New South Wales - Randwick Campus

AUSTRALIA
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Atte Meretoja

University of Helsinki

FINLAND
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Alexander G Mathioudakis

The University of Manchester

UNITED KINGDOM
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Jorge Simões

University of Twente

NETHERLANDS
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Santosh Gaihre

University of Aberdeen

UNITED KINGDOM
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Taleb H. Al‐Tel

-

UNITED ARAB EMIRATES
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Dr Danish Ahmad

University of Canberra

AUSTRALIA
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Md Juwel Rana

McGill University

CANADA
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Norma Bulamu

Flinders University

AUSTRALIA
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MUNJAE LEE

Ajou University School of Medicine

SOUTH KOREA
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Nada Binmadi

-

SAUDI ARABIA
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Munkhtuya Tumurkhuu

Lecturer

International University of Health and Welfare

JAPAN
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Kehinde Obamiro

-

AUSTRALIA
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Jing Sun

Professor

Griffith University Griffith Health

AUSTRALIA
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Madhan Balasubramanian

Senior Lecturer in Health Care Management

Flinders University

AUSTRALIA
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Rania Salama

Macquarie University

AUSTRALIA
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Keshab Deuba

Karolinska Institutet

SWEDEN
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Mohamed A. Abdelgawad

-

SAUDI ARABIA
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Mohamed Abdelbakky

-

SAUDI ARABIA
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Farah Al-Marzooq

-

UNITED ARAB EMIRATES
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Richard Burns

The Australian National University

AUSTRALIA
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Biswajit Banik

Lecturer

Federation University

AUSTRALIA
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Lemma Negesa Bulto

Flinders University

AUSTRALIA
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Francesca Sanna

Telethon Kids Institute

AUSTRALIA
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Kebede Beyene

Assistant Professor of Pharmacy Administration

University of Health Sciences and Pharmacy

UNITED STATES
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Garland Culbreth

Institute for Health Metrics and Evaluation

UNITED STATES
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Sameh S. M. Soliman

-

UNITED ARAB EMIRATES
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Omar Awad Alsaidan

-

SAUDI ARABIA
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Om Prakash Kurmi

Coventry University

UNITED KINGDOM
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Mohammad Enamul Hoque

University of Western Australia

AUSTRALIA
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Hamed Markazi Moghadam

Leibniz University Hannover

GERMANY
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John Dube

University of Windsor

CANADA
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Abdullah Mamun

University of Queensland

AUSTRALIA
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Edmond Sanganyado

Northumbria University

UNITED KINGDOM
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Julie Brown

Head

The George Institute for Global Health

AUSTRALIA
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Mei Li

University of Groningen

NETHERLANDS
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Lalit Yadav

Flinders University

AUSTRALIA
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Evangelia Eirini Tsermpini

Stanford University

UNITED STATES
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Stefan Listl

University Hospital Heidelberg

GERMANY
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Jagdish Khubchandani

Professor

University of New Mexico

UNITED STATES
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Michael Schwarzinger

INSERM

FRANCE
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WILLIAMS AGYEMANG-DUAH

Teaching and Research Assistant

Queen's University

CANADA
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Abanoub Riad

Assistant Professor

Masaryk University

CZECH REPUBLIC
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Colin Simpson

Victoria University of Wellington

NEW ZEALAND
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Subas Neupane

Tampere University

FINLAND
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Yanzhong Wang

King’s College London

UNITED KINGDOM
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Arkadiusz Dziedzic

-

POLAND
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Drona Rasali

Adjunct Professor

The University of British Columbia

CANADA
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Christopher R. Cederroth

Karolinska Institutet

SWEDEN
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Paulo Bettencourt

University of Oxford

UNITED KINGDOM
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BILLINGSLEY KAAMBWA

Flinders University

AUSTRALIA
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Arafa Musa

-

SAUDI ARABIA
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Karen M. Tabb

University of Illinois at Urbana-Champaign

UNITED STATES
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Cristiana ABBAFATI

Sapienza University of Rome

ITALY
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Ranjan Solanki

Associate Professor, Systemic Pathology

Touro College

UNITED STATES
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Sojib Bin Zaman

Assistant Professor

James Madison University

UNITED STATES
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Carla Fornari

University of Milano-Bicocca

ITALY
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Dr. Zubair Ahmed Ratan

University of Wollongong

AUSTRALIA
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Mario Valenti

Humanitas University

ITALY
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Adquate Mhlanga

Loyola University Chicago

UNITED STATES
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