Hany A. Omar
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Articles (20)
Hepatocellular carcinoma (HCC) significantly contributes to cancer‐related mortality due to the limited response of HCC to current anticancer therapies, thereby necessitating more effective treatment approaches. Energy restriction mimetic agents (ERMAs) have emerged as potential therapies in targeting the Warburg effect, a unique metabolic process in cancer cells. However, ERMAs exhibit limited efficacy when used as monotherapy. Additionally, ERMAs have been found to induce autophagy in cancer cells. The role of autophagy in cancer survival remains a subject of debate. Thus, it is crucial to ascertain whether ERMA‐induced autophagy is a mechanism for cell survival or cell death in HCC. Our study aims to investigate the effect of autophagy inhibition on the survival of HCC cells treated with ERMAs while also examining the potential of combining an autophagy inhibitor such as spautin‐1 with ERMAs to enhance HCC cell death. Our results suggest a cytoprotective role for ERMA‐induced autophagy in HCC cells, as combining the autophagy inhibitor spautin‐1 with ERMAs effectively suppressed ERMA‐induced autophagy and synergistically enhanced their antitumor activity. The treatment combination promoted HCC death through apoptosis, cell cycle arrest, and inhibition of AKT and ERK activation, which are known to play a key role in cellular proliferation. Collectively, our findings highlight a potential strategy to combat HCC by combining energy restriction with autophagy inhibition.
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Collaborators (80)
Patricia Cullen
UNSW Sydney
Cijo George Vazhappilly
-
Hanan S Anbar
-
Tomasz Miazgowski
Pomeranian Medical University
Christine Mpundu-Kaambwa
Flinders University
Benn Sartorius
Associate Professor/Principal Research Fellow
University of Queensland
Sumaira Mubarik
Assistant Professor
University of Groningen
Yafei Si
University of Melbourne
Alberto Freitas
Assistant Professor
Faculty of Medicine of the University of Porto
Derek Chew
Assistant Professor
University of Calgary
Mohammed Elmowafy
-
Sheng-Chia Chung
University College London
Lennart Reifels
University of Melbourne
Moien AB Khan
-
Ameeduzzafar Zafar
-
Jerry John Nutor
University of California, San Francisco
Nuno Taveira
Full Professor
Instituto Universitário de Ciências da Saúde
Yannick Béjot
Professor of Neurology
University of Burgundy
Luís Belo
Assistant Professor with Habilitation
Faculty of Pharmacy, University of Lisbon
John McGrath
Aarhus University
Serge Resnikoff
Visiting Professor
University of New South Wales - Randwick Campus
Atte Meretoja
University of Helsinki
Alexander G Mathioudakis
The University of Manchester
Jorge Simões
University of Twente
Santosh Gaihre
University of Aberdeen
Taleb H. Al‐Tel
-
Dr Danish Ahmad
University of Canberra
Md Juwel Rana
McGill University
Norma Bulamu
Flinders University
MUNJAE LEE
Ajou University School of Medicine
Nada Binmadi
-
Munkhtuya Tumurkhuu
Lecturer
International University of Health and Welfare
Kehinde Obamiro
-
Jing Sun
Professor
Griffith University Griffith Health
Madhan Balasubramanian
Senior Lecturer in Health Care Management
Flinders University
Rania Salama
Macquarie University
Keshab Deuba
Karolinska Institutet
Mohamed A. Abdelgawad
-
Mohamed Abdelbakky
-
Farah Al-Marzooq
-
Richard Burns
The Australian National University
Biswajit Banik
Lecturer
Federation University
Lemma Negesa Bulto
Flinders University
Francesca Sanna
Telethon Kids Institute
Kebede Beyene
Assistant Professor of Pharmacy Administration
University of Health Sciences and Pharmacy
Garland Culbreth
Institute for Health Metrics and Evaluation
Sameh S. M. Soliman
-
Omar Awad Alsaidan
-
Om Prakash Kurmi
Coventry University
Mohammad Enamul Hoque
University of Western Australia
Hamed Markazi Moghadam
Leibniz University Hannover
John Dube
University of Windsor
Abdullah Mamun
University of Queensland
Edmond Sanganyado
Northumbria University
Julie Brown
Head
The George Institute for Global Health
Mei Li
University of Groningen
Lalit Yadav
Flinders University
Evangelia Eirini Tsermpini
Stanford University
Stefan Listl
University Hospital Heidelberg
Jagdish Khubchandani
Professor
University of New Mexico
Michael Schwarzinger
INSERM
WILLIAMS AGYEMANG-DUAH
Teaching and Research Assistant
Queen's University
Abanoub Riad
Assistant Professor
Masaryk University
Colin Simpson
Victoria University of Wellington
Subas Neupane
Tampere University
Yanzhong Wang
King’s College London
Arkadiusz Dziedzic
-
Drona Rasali
Adjunct Professor
The University of British Columbia
Christopher R. Cederroth
Karolinska Institutet
Paulo Bettencourt
University of Oxford
BILLINGSLEY KAAMBWA
Flinders University
Arafa Musa
-
Karen M. Tabb
University of Illinois at Urbana-Champaign
Cristiana ABBAFATI
Sapienza University of Rome
Ranjan Solanki
Associate Professor, Systemic Pathology
Touro College
Sojib Bin Zaman
Assistant Professor
James Madison University
Carla Fornari
University of Milano-Bicocca
Dr. Zubair Ahmed Ratan
University of Wollongong
Mario Valenti
Humanitas University
Adquate Mhlanga
Loyola University Chicago
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