Harish Poptani

Professor and Chair of the Center for Preclinical Imaging

University of Liverpool

United Kingdom

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Professor Harish Poptani is the Chair of the Center for Preclinical Imaging at the University of Liverpool, United Kingdom. His research primarily focuses on advanced imaging techniques and therapeutic approaches in neurological disorders and cancer, as highlighted in his recent publications on gene therapy, glioblastoma, and preclinical models of disease. Professor Poptani's work aims to enhance understanding and treatment strategies in complex pathologies through innovative methodologies in preclinical imaging.

Articles (26)

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2025

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2020

Collaborators (8)

Joseph J. Sacco

Clinical Senior Lecturer

University of Liverpool

UNITED KINGDOM

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Ian Copple

University of Liverpool

UNITED KINGDOM

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Nitish Katoch

Research Professor

Kyungpook National University

SOUTH KOREA

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Chi Hin Brian Ho

Clinical Lecturer

University of Liverpool

UNITED KINGDOM

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SANJEEV CHAWLA, PhD, DABMP

Research Assistant Professor

University of Pennsylvania

UNITED STATES

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Bettina Wilm

Senior Lecturer

University of Liverpool

UNITED KINGDOM

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Judy M. Coulson

University of Liverpool

UNITED KINGDOM

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Atul Singh Minhas

Macquarie University

AUSTRALIA

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Harish Poptani

Research Interests

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Articles (26)

Methodology for generating chorioallantoic membrane patient-derived xenograft (CAM-PDX) models of pleural mesothelioma and performing preclinical imaging for the translation of cancer studies and drug screening.

Effect of disease progression on CSF-directed AAV gene therapy in a large brain animal model of lysosomal storage disease.

Evaluating the Combined Effect of a Choline Kinase Inhibitor and Temozolomide Therapy in a Mouse Model of Glioblastoma Using &lt;sup&gt;1&lt;/sup&gt;H MR Spectroscopy and IVIM-DWI.

Hypoxia Dependent Inhibition of Glioblastoma Cell Proliferation, Invasion, and Metabolism by the Choline-Kinase Inhibitor JAS239

Magnetic particle imaging: The need for standardized approaches

The LIDPAD Mouse Model Captures the Multisystem Interactions and Extrahepatic Complications in MASLD.

Widespread correction of brain pathology in feline alpha-mannosidosis by dose escalation of intracisternal AAV vector injection.

Pleiotropic effects of trisomy and pharmacologic modulation on structural, functional, molecular, and genetic systems in a Down syndrome mouse model.

Microcephaly with a disproportionate hippocampal reduction, stem cell loss and neuronal lipid droplet symptoms in Trappc9 KO mice

FGF21 serum dynamics are linked with hepatectomy outcomes &amp; its analogue enhances liver regeneration

FGF21 serum dynamics are linked with hepatectomy outcomes &amp; its analogue enhances liver regeneration

The LIDPAD Mouse Model Captures the Multisystem Interactions and Extrahepatic Complications in MASLD (Adv. Sci. 35/2024)

Multiparametric MRI based assessment of kidney injury in a mouse model of ischemia reperfusion injury.

Validation of multiparametric MRI based prediction model in identification of pseudoprogression in glioblastomas.

Deep learning-based quantitative evaluation of tumour and necrosis in whole slide scans of rodent models of glioblastoma

In Vivo Tumorigenicity of the 20q11.21 Amplicon in an Engraftment Model of hPSCs and Differentiated Liver Cells

Assessing Tumour Haemodynamic Heterogeneity and Response to Choline Kinase Inhibition Using Clustered Dynamic Contrast Enhanced MRI Parameters in Rodent Models of Glioblastoma

Pharmacological Activation of Nrf2 Enhances Functional Liver Regeneration.

High‐frequency electrical properties tomography at 9.4T as a novel contrast mechanism for brain tumors

Physiological Imaging Methods for Evaluating Response to Immunotherapies in Glioblastomas

Differentiating Nonenhancing Grade II Gliomas from Grade III Gliomas Using Diffusion Tensor Imaging and Dynamic Susceptibility Contrast MRI

Diffusion kurtosis imaging for characterizing tumor heterogeneity in an intracranial rat glioblastoma model

Diffusion- and Perfusion-Weighted Magnetic Resonance Imaging Methods in Nonenhancing Gliomas

Measuring Kidney Perfusion, pH, and Renal Clearance Consecutively Using MRI and Multispectral Optoacoustic Tomography

Assessing Human Embryonic Stem Cell-Derived Dopaminergic Neuron Progenitor Transplants Using Non-invasive Imaging Techniques

Does the application of diffusion weighted imaging improve the prediction of survival in patients with resected brain metastases? A retrospective multicenter study

Collaborators (8)

Joseph J. Sacco

Ian Copple

Nitish Katoch

Chi Hin Brian Ho

SANJEEV CHAWLA, PhD, DABMP

Bettina Wilm

Judy M. Coulson

Atul Singh Minhas

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Evaluating the Combined Effect of a Choline Kinase Inhibitor and Temozolomide Therapy in a Mouse Model of Glioblastoma Using <sup>1</sup>H MR Spectroscopy and IVIM-DWI.

FGF21 serum dynamics are linked with hepatectomy outcomes & its analogue enhances liver regeneration

FGF21 serum dynamics are linked with hepatectomy outcomes & its analogue enhances liver regeneration