Helen Thomas

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Head of Clinical Trial Statistics

NHS Blood and Transplant

United Kingdom

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About

Helen Thomas is the Head of Clinical Trial Statistics at NHS Blood and Transplant in the UK. Her research interests focus on clinical trials in hematology and transfusion medicine, as demonstrated by her recent articles on red cell transfusion thresholds and high-dose cryoprecipitate administration in trauma patients. Additionally, she has contributed to studies evaluating AI in detecting thromboembolic events and the impact of SARS-CoV-2 on immunosuppressed populations.

Recent Grants

Grant: Open

Prothrombin complex concentrate versus fresh frozen plasma for bleeding in adults undergoing heart surgery (PROPHESY-2 trial).

Open Date: 2023-09-01

Close Date: 2027-04-30

Grant: Close

Oxygenated Hypothermic Machine Perfusion in Pancreas Preservation for Transplantation

Open Date: 2023-07-01

Close Date: 2026-06-30

Grant: Close

Mass evaluation of lateral flow immunoassays for the detection of SARS-CoV-2 antibody responses in immunosuppressed people (MELODY Study)

Open Date: 2021-11-15

Close Date: 2023-04-17

Grant: Close

Should we ligate haemodialysis fistulas in patients once they have been transplanted successfully? A feasibility study

Open Date: 2021-09-01

Close Date: 2023-08-01

Grant: Close

A multi-centre, prospective, double-blinded, pilot study evaluating artificial intelligence driven automatic detection of proximal deep vein thrombosis (DVT).

Open Date: 2021-04-01

Close Date: 2022-07-01

Articles (11)

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2025

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2025

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2025

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2024

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2024

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2024

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2023

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2023

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2022

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James Griffiths

Head of Clinical Trial Operations

NHS Blood and Transplant

UNITED KINGDOM

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Peter Lanyon

Honorary Professor

University of Nottingham

UNITED KINGDOM

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University of the West of England

UNITED KINGDOM

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Nicola Curry

UNITED KINGDOM

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James Shaw

Clinical Professor/Consultant

Newcastle University

UNITED KINGDOM

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Helen Thomas

Research Interests

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About

Recent Grants

Articles (11)

How low can we go? Comparison of liberal and restrictive red cell transfusion thresholds in paediatric allogeneic haematopoietic stem cell transplantation: A randomized multicentre feasibility trial.

Multicenter Double-Blind Study Evaluating AI-Driven Detection of Proximal Deep Vein Thrombosis

Impact of SARS-CoV-2 spike antibody positivity on infection and hospitalisation rates in immunosuppressed populations during the omicron period: the MELODY study.

Tranexamic acid versus placebo to prevent bleeding in patients with haematological malignancies and severe thrombocytopenia (TREATT): a randomised, double-blind, parallel, phase 3 superiority trial.

Early high-dose cryoprecipitate to reduce mortality in adult patients with traumatic haemorrhage: the CRYOSTAT-2 RCT with cost-effectiveness analysis

SIGNET: protocol for a multicentre, single-blind prospective, group sequential, randomised controlled trial to evaluate the benefits of a single dose of simvastatin given to potential organ donors declared dead by neurological criteria on outcomes in organ recipients

Early and Empirical High-Dose Cryoprecipitate for Hemorrhage After Traumatic Injury

A pragmatic, open-label, randomized controlled trial of Plasma-Lyte-148 versus standard intravenous fluids in children receiving kidney transplants (PLUTO).

Multicentre randomised controlled trial: protocol for Plasma-Lyte Usage and Assessment of Kidney Transplant Outcomes in Children (PLUTO).

The CRYOSTAT2 trial: The rationale and study protocol for a multi‐Centre, randomised, controlled trial evaluating the effects of early high‐dose cryoprecipitate in adult patients with major trauma haemorrhage requiring major haemorrhage protocol activation

Red cell transfusion in outpatients with myelodysplastic syndromes: a feasibility and exploratory randomised trial

Collaborators (14)

laura green

Daniel McAuley

Wesley Nathan Hayes

Michael J. R. Desborough

James Griffiths

Peter Lanyon

Daphne Kounali

Neil Sheerin

Alison Deary

Mark Peters

Guy MacGowan

J. Benger

Nicola Curry

James Shaw

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