Helen Wright

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Senior Lecturer

University of Liverpool

United Kingdom

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About

Helen Wright is a Senior Lecturer at the University of Liverpool, UK. Her research primarily focuses on the role of neutrophils in various conditions, including rheumatoid arthritis, immune-mediated inflammatory diseases, and aging. Recent publications highlight her investigations into cytokine-induced transcriptional changes, metabolomics analyses, and the complex mechanisms of neutrophils related to inflammation and health.

Recent Grants

Grant: Close

Neutrophil extracellular traps (NETs) as a therapeutic target for the treatment of auto-immune inflammatory disease

Open Date: 2021-09-01

Close Date: 2022-08-01

Grant: Close

Metabolic reprogramming of human neutrophils during inflammation

Open Date: 2019-10-01

Close Date: 2023-09-01

Grant: Close

Biomarkers to predict response to biologic therapy for the stratification of patients to appropriate therapy in rheumatoid arthritis

Open Date: 2019-03-01

Close Date: 2020-02-01

Grant: Close

Biomarkers in Inflammation

Open Date: 2018-05-01

Close Date: 2020-11-01

Grant: Close

Computational modelling and functional investigation of neutrophil activation and plasticity in inflammatory disease

Open Date: 2017-06-01

Close Date: 2022-05-01

Articles (17)

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2025

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2024

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2022

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2021

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2021

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2021

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2021

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2021

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Bangor University

UNITED KINGDOM

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Helen Wright

Research Interests

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Contact this professor

About

Recent Grants

Articles (17)

Cytokine-Induced Transcriptional Changes in Human Neutrophils Reveal Immune Regulatory Plasticity

An NMR Metabolomics Analysis Pipeline for Human Neutrophil Samples with Limited Source Material

The complex role of neutrophils in healthy aging, inflammaging, and frailty

Autophagy inhibitors block pathogenic NET release in immune-mediated inflammatory disease without impairing host defence

Complexity of the neutrophil transcriptome in early and severe rheumatoid arthritis: a role for microRNAs?

The small molecule inhibitor 3PO is a modulator of neutrophil metabolism, ROS production, and NET release

Circulating neutrophil extracellular trap-forming neutrophils in rheumatoid arthritis exacerbation are majority dual endothelin-1/signal peptide receptor+ subtype

Metabolic Profiling of Rheumatoid Arthritis Neutrophils Reveals Altered Energy Metabolism That Is Not Affected by JAK Inhibition

Anti-Inflammatory Effects and Decreased Formation of Neutrophil Extracellular Traps by Enoxaparin in COVID-19 Patients

Matrix metalloproteinase-13 is fully activated by neutrophil elastase and inactivates its serpin inhibitor, alpha-1 antitrypsin: Implications for osteoarthritis

Internalization of Neutrophil-Derived Microvesicles Modulates TNFα-Stimulated Proinflammatory Cytokine Production in Human Fibroblast-Like Synoviocytes

Type I interferon regulates cytokine-delayed neutrophil apoptosis, reactive oxygen species production and chemokine expression

Isolation of microvesicles from human circulating neutrophils

Neutrophils in the Pathogenesis of Rheumatoid Arthritis and Systemic Lupus Erythematosus: Same Foe Different M.O.

Rheumatoid Arthritis Synovial Fluid Neutrophils Drive Inflammation Through Production of Chemokines, Reactive Oxygen Species, and Neutrophil Extracellular Traps

The clinical significance of antinuclear antibodies and specific autoantibodies in juvenile and adult systemic lupus erythematosus patients

APPA (apocynin and paeonol) modulates pathological aspects of human neutrophil function, without supressing antimicrobial ability, and inhibits TNFα expression and signalling

Collaborators (5)

Steven Edwards

Patrick A. Eyers

Robert Moots

David Wilkinson

Elinor Chapman

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