Henning Walczak

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Alexander-von-Humboldt Professor of Biochemistry

University of Cologne

Germany

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About

Henning Walczak is the Alexander-von-Humboldt Professor of Biochemistry at Universität zu Köln, Germany. His research focuses on various aspects of biochemistry, including the mechanisms underlying lipodystrophy and metabolic syndromes, cell death pathways, and cancer immunology. Recent articles highlight his work on the role of STING in necroptosis, the effects of regulatory T cell depletion on glioblastoma, and the efficacy of novel therapeutic approaches in cancer treatment and COVID-19.

Recent Grants

Grant: Close

Neuro-oncological precision nanomedicines

Open Date: 2018-09-01

Close Date: 2021-08-31

Grant: Close

Cancer Immunotherapy Catalyst Network

Open Date: 2015-09-01

Close Date: 2020-08-31

Grant: Close

Understanding and harnessing TRAIL's pro-tumourigenic and pro-apoptotic in-vivo functions for improved cancer therapy

Open Date: 2014-08-01

Close Date: 2019-07-31

Grant: Close

Systems Analysis of TNF and TRAIL Signalling Pathways in Hepatocytes

Open Date: 2013-02-01

Close Date: 2013-08-30

Grant: Close

Studies of linear ubiquitin and different modes of cell death induction by TNFfamily members in aetiology and treatment of auto-immunity

Open Date: 2013-01-01

Close Date: 2018-12-31

Articles (15)

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2025

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2021

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2020

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2020

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2020

Collaborators (9)

Johannes Laengle

Medical University of Vienna

AUSTRIA

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Oliver Pusch

Associate Professor

Medical University of Vienna

AUSTRIA

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Angelika Hausser

University of Stuttgart

GERMANY

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Silvia von Karstedt

GERMANY

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Sarah Conduit

MONASH UNIVERSITY

AUSTRALIA

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Julian Pardo

Professor

Universidad de Zaragoza

SPAIN

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Alessandro Annibaldi

University of Cologne

GERMANY

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Holger Grüll

Professor

University of Cologne

GERMANY

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Daniel Gray

Joint Division Head and Laboratory Head

Walter and Eliza Hall Institute of Medical Research

AUSTRALIA

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Henning Walczak

Research Interests

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About

Recent Grants

Articles (15)

Inactivation of PI3K-C2α deregulates cell death pathways and sensitizes to endotoxic shock

Linear ubiquitination prevents lipodystrophy and obesity-associated metabolic syndrome

Functional synapses between neurons and small cell lung cancer

MLKL activity requires a splicing-regulated, druggable intramolecular interaction

Persistent epigenetic memory of SARS-CoV-2 mRNA vaccination in monocyte-derived macrophages

Regulatory T cell depletion promotes myeloid cell activation and glioblastoma response to anti-PD1 and tumor-targeting antibodies

STING induces ZBP1-mediated necroptosis independently of TNFR1 and FADD

A novel mouse model recapitulating the MMR-defective SCLC subtype uncovers an actionable sensitivity to immune checkpoint blockade

Efficacy and safety of asunercept, a CD95L-selective inhibitor, in hospitalised patients with moderate-to-severe COVID-19: ASUNCTIS, a multicentre, randomised, open-label, controlled, phase 2 trial.

Cancer-associated fibroblasts shape early myeloid cell response to chemotherapy-induced immunogenic signals in next generation tumor organoid cultures

Harnessing TRAIL-induced cell death for cancer therapy: a long walk with thrilling discoveries

Dual roles for LUBAC signaling in thymic epithelial cell development and survival

An unexpected turn of fortune: targeting TRAIL-Rs in KRAS-driven cancer.

Cancer Cells Employ Nuclear Caspase-8 to Overcome the p53-Dependent G2/M Checkpoint through Cleavage of USP28.

Death Receptors and Their Ligands in Inflammatory Disease and Cancer.

Collaborators (9)

Johannes Laengle

Oliver Pusch

Angelika Hausser

Silvia von Karstedt

Sarah Conduit

Julian Pardo

Alessandro Annibaldi

Holger Grüll

Daniel Gray

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