Henrique Borges da Silva

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Assistant Professor (Senior Associate Consultant I)

Mayo Clinic

United States

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Recent Grants

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DEFINING THE FUNCTION OF EXTRACELLULAR ATP SENSING FOR MEMORY CD8+ T CELL GENERATION AND LONGEVITY

Open Date: 2020-08-17

Close Date: 2022-07-31

Grant: Close

Defining the function of extracellular ATP sensing for memory CD8+ T cell generation and longevity

Open Date: 2019-08-10

Close Date: 2020-07-31

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Collaborators (8)

Michele Zanoni

Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori

ITALY

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Kristin Renkema

Associate Professor

Grand Valley State University

UNITED STATES

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Dominique Hoelzinger

Assistant Professor

Mayo Clinic Arizona

UNITED STATES

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Stephen C. Jameson

University of Minnesota Medical School

UNITED STATES

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Maggie Zhou

Columbia University

UNITED STATES

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Nicholas Maurice

University of Minnesota

UNITED STATES

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Sara Hamilton

University of Minnesota

UNITED STATES

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Nicholas Jarjour

University of Minnesota

UNITED STATES

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Henrique Borges da Silva

Research Interests

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Recent Grants

Articles (18)

CD8<sup>+</sup> T Cells Keep Their (K<sup>+</sup>)urrency for Function

Location versus ID: what matters to lung-resident memory T cells?

Amphipathic Liponecrosis Impairs Bacterial Clearance and Causes Infection During Sterile Inflammation

Editorial: Therapy resistance in tumor microenvironment: metabolic reprogramming and purinergic signaling

T cell-specific P2RX7 favors lung parenchymal CD4<sup>+</sup> T cell accumulation in response to severe lung infections

Tissue-and temporal-specific roles of extracellular ATP on T cell metabolism and function

P2RX7 Enhances Tumor Control by CD8+ T Cells in Adoptive Cell Therapy

Extracellular vesicle proteomic analysis leads to the discovery of HDGF as a new factor in multiple myeloma biology

The Extracellular ATP Receptor P2RX7 Imprints a Promemory Transcriptional Signature in Effector CD8+ T Cells

Responsiveness to interleukin-15 therapy is shared between tissue-resident and circulating memory CD8 + T cell subsets

Editorial: Extracellular Nucleotides in Lymphocyte Function

Engagement of the costimulatory molecule ICOS in tissues promotes establishment of CD8<sup>+</sup> tissue-resident memory T cells.

Editorial overview: Immunometabolism.

Navigating in Deep Waters: How Tissue Damage and Inflammation Shape Effector and Memory CD8<sup>+</sup> T Cell Responses.

CD8<sup>+</sup> T cell self-tolerance permits responsiveness but limits tissue damage.

Metabolic regulation of tissue-resident memory CD8<sup>+</sup> T cells.

P2Y11: The CD4 T cell mitochondrial shepherd.

KLRG1<sup>+</sup> Memory CD8 T Cells Combine Properties of Short-Lived Effectors and Long-Lived Memory.

Collaborators (8)

Michele Zanoni

Kristin Renkema

Dominique Hoelzinger

Stephen C. Jameson

Maggie Zhou

Nicholas Maurice

Sara Hamilton

Nicholas Jarjour

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