Hidetaka Akita

Professor

Tohoku University

Japan

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Hidetaka Akita is a Professor at Tohoku University in Japan. His research focuses on lipid nanoparticles for mRNA delivery, including the optimization of immunogenicity, and the development of innovative vaccine carriers. He has made significant contributions to understanding the immune response to lipid-based therapeutics and their application in treating autoimmune diseases and enhancing anticancer immunity.

Articles (14)

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2025

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2023

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2022

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2022

Collaborators (8)

Etsuo Yonemochi

Professor

JAPAN

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Hiroto Hatakeyama

Professor

Chiba University

JAPAN

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Keiji Itaka

Tokyo Medical and Dental University

JAPAN

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Hideyuki Nakanishi

Assistant Professor

Tokyo Medical and Dental University

JAPAN

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Hiroyuki Suzuki

Chiba University

JAPAN

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Ryosuke Kobayashi

Assistant Professor

Rakuno Gakuen University

JAPAN

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Shigeki Aoki

Chiba University

JAPAN

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Yuki Noguchi

Chugai Pharmaceutical

JAPAN

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Hidetaka Akita

Research Interests

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About

Articles (14)

Modulating Immunogenicity and Reactogenicity in mRNA-Lipid Nanoparticle Vaccines through Lipid Component Optimization

The Effect of Cholesterol Content on the Adjuvant Activity of Nucleic-Acid-Free Lipid Nanoparticles

Effect of Anti-PEG Antibody on Immune Response of mRNA-Loaded Lipid Nanoparticles

A Lipid Nanoparticle-Based Method for the Generation of Liver-Specific Knockout Mice

Comprehensive Evaluation of Lipid Nanoparticles and Polyplex Nanomicelles for Muscle-Targeted mRNA Delivery

Tolerogenic Lipid Nanoparticles for Delivering Self-Antigen mRNA for the Treatment of Experimental Autoimmune Encephalomyelitis

Development of an Alcohol Dilution–Lyophilization Method for the Preparation of mRNA-LNPs with Improved Storage Stability

Delivering mRNA to Secondary Lymphoid Tissues by Phosphatidylserine-Loaded Lipid Nanoparticles

Reactivation of Anticancer Immunity by Resetting Interorgan Crosstalk in Immune-Suppressive Cells with a Nanoparticulated Anti-Inflammatory Drug

Ready-to-Use-Type Lyophilized Lipid Nanoparticle Formulation for the Postencapsulation of Messenger RNA

siRNA delivery to lymphatic endothelial cells via ApoE-mediated uptake by lipid nanoparticles

Development of a Ready-to-Use-Type RNA Vaccine Carrier Based on an Intracellular Environment-Responsive Lipid-like Material with Immune-Activating Vitamin E Scaffolds

Delivery of aPD-L1 antibody to i.p. tumors via direct penetration by i.p. route: Beyond EPR effect

Cellular Binding and Internalization Assay for an Anti-FcγRIIB Antibody Using Human Liver Non-parenchymal Cells

Collaborators (8)

Etsuo Yonemochi

Hiroto Hatakeyama

Keiji Itaka

Hideyuki Nakanishi

Hiroyuki Suzuki

Ryosuke Kobayashi

Shigeki Aoki

Yuki Noguchi

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