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Hideyuki Okano

Dean and Professor

Keio University School of Medicine

Japan

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Research Interests

Tissue Engineering

90%

Cell Biology

80%

Stem Cell Research

60%

Neuroprotection

50%

Genome Engineering

30%

Spinal Cord Injury

30%

Ipsc

30%

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Articles19

Protocol for the induction of human spinal motor neurons from human induced pluripotent stem cells for studying amyotrophic lateral sclerosis

Article Link

Year:

2025

Ropinirole Functions Through a Dopamine Receptor D2‐Independent Mechanism to Ameliorate Amyotrophic Lateral Sclerosis Phenotypes in TARDBP‐Mutant iPSC‐Derived Motor Neurons

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Year:

2025

Phase separated condensates of ATRX regulate neural progenitor identity

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Year:

2025

Experimental basis for generating nonhuman primate models of frontotemporal dementia and Alzheimer's disease

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Year:

2025

Regenerative medicine strategies for chronic complete spinal cord injury

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Year:

2024

Human-Induced Pluripotent Stem Cell-Derived Neural Progenitor Cells Showed Neuronal Differentiation, Neurite Extension, and Formation of Synaptic Structures in Rodent Ischemic Stroke Brains

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Year:

2024

Spinal cord motor neuron phenotypes and polygenic risk scores in sporadic amyotrophic lateral sclerosis: deciphering the disease pathology and therapeutic potential of ropinirole hydrochloride

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Year:

2024

Dynamic molecular network analysis of iPSC-Purkinje cells differentiation delineates roles of ISG15 in SCA1 at the earliest stage

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Year:

2024

A Novel Directed Seed-Based Connectivity Analysis Toolbox Applied to Human and Marmoset Resting-State FMRI

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Year:

2024

Inhibitory Roles of Apolipoprotein E Christchurch Astrocytes in Curbing Tau Propagation Using Human Pluripotent Stem Cell-Derived Models

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Year:

2024

A Review of Treatment Methods Focusing on Human Induced Pluripotent Stem Cell-Derived Neural Stem/Progenitor Cell Transplantation for Chronic Spinal Cord Injury

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Year:

2023

The Germinal Origin of Salivary and Lacrimal Glands and the Contributions of Neural Crest Cell-Derived Epithelium to Tissue Regeneration

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Year:

2023

Protein profiling of extracellular vesicles from iPSC-derived astrocytes of patients with ALS/PDC in Kii peninsula

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Year:

2023

Neuroprotective Effects of Genome-Edited Human iPS Cell-Derived Neural Stem/Progenitor Cells on Traumatic Brain Injury

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Year:

2023

Mesenchymal properties of iPSC-derived neural progenitors that generate undesired grafts after transplantation

Article Link

Year:

2023

A human induced pluripotent stem cell model from a patient with hereditary cerebral small vessel disease carrying a heterozygous R302Q mutation in HTRA1

Article Link

Year:

2023

Rapid and Robust Multi-Phenotypic Assay System for ALS Using Human iPS Cells with Mutations in Causative Genes

Article Link

Year:

2023

A review of regenerative therapy for spinal cord injury using human iPS cells

Article Link

Year:

2023

A set-theoretic definition of cell types with an algebraic structure on gene regulatory networks and application in annotation of RNA-seq data

Article Link

Year:

2023

Collaborators11

Narihito Nagoshi

Keio University School of Medicine

JAPAN

Yoshifumi Hirokawa

Associate Professor

Mie university

JAPAN

Takuto Okuno

Assistant Professor

University of Tokyo

JAPAN

Hideyo Ohuchi

Okayama University

JAPAN

Tsutomu Nohno

Professor

Kawasaki Medical School

JAPAN

Syoichi Tashiro

Lecturer

School of Medicine, Kyorin University

JAPAN

Ichiro Yabe

Professor

Hokkaido Daigaku

JAPAN

Masayasu Okada

Niigata University

JAPAN

Yo Mabuchi

Fujita Health University

JAPAN

Satoru Morimoto

Project Assistant Professor

Keio University School of Medicine

JAPAN

Hidenori Homma

Institute of Science Tokyo

JAPAN

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