Hien M. Nguyen

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Associate Professor

Iowa State University

United States

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Hien M. Nguyen is an Associate Professor at the University of Iowa, USA. His research primarily focuses on the design and synthesis of selective ligands, the development of novel antimicrobial peptides, and the exploration of heparan sulfate mimetics for cancer treatment. Recent articles highlight his investigations into molecular interactions and enzymatic activities related to heparanase, as well as advancements in glycoside synthesis techniques.

Recent Grants

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Catalytic Methods for Stereoselective 1,2-Cis Glycosylation

Open Date: 2016-09-01

Close Date: 2020-05-31

Grant: Close

Synthesis and Evaluation of Zwitterionic Carbohydrate Immunostimulants

Open Date: 2016-01-15

Close Date: 2017-12-31

Grant: Close

Synthesis of Complex Carbohydrates.

Open Date: 2012-04-01

Close Date: 2017-03-31

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2021

Collaborators (4)

Long Luo

Wayne State University

UNITED STATES

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H. Bernhard Schlegel

Professor

Wayne State University

UNITED STATES

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Vishaka Pathiranage

Graduate Research and Teaching Assistant

Wayne State University

UNITED STATES

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Alice Walker

Assistant Professor

Wayne State University

UNITED STATES

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Hien M. Nguyen

Research Interests

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About

Recent Grants

Articles (25)

Why is thiol unexpectedly less reactive but more selective than alcohol in phenanthroline-catalyzed 1,2-cis O- and S-furanosylations?

Investigation into the binding domains of platelet factor 4 unlocks new avenues for the design and synthesis of selective sulfated pseudo-tetrasaccharide aminoglycoside ligands

Truncated and Disubstituted (P4K and L7R) Oncocin Peptides Target the Ribosome with Improved Antibacterial Activity

Heparanase-Inhibiting Polymeric Heparan Sulfate Mimetic Attenuates Myeloma Tumor Growth and Bone Metastasis

From Docking and Molecular Dynamics to Experimental Discovery: Exploring the Hydrophobic Landscapes of Heparanase to Design Potent Inhibitors

Could Hydrophobicity of Sulfated Pseudo-Trisaccharides Derived from Repurposing Aminoglycoside Tobramycin Modulate the Enzymatic Activity of Heparanase?

Design of Paromomycin and Neomycin as Sulfated and Hydrophobic Glycans to Target Heparanase-Driven Tumor Progression and Metastasis

Phenanthroline-Assisted Stereoselective Synthesis of 2-Deoxy Glycosides

Rhodium-Catalyzed Allylic Amination for the Enantioselective Synthesis of Tertiary β-Fluoroamines

Highly stereoselective synthesis of α-glycosylated carboxylic acids by phenanthroline catalysis

Cooperative Catalysis in Stereoselective O- and N-Glycosylations with Glycosyl Trichloroacetimidates Mediated by Singly Protonated Phenanthrolinium Salt and Trichloroacetamide

Scope and Mechanistic Probe into Asymmetric Synthesis of α-Trisubstituted-α-Tertiary Amines by Rhodium Catalysis

Rational Design and Expedient Synthesis of Heparan Sulfate Mimetics from Natural Aminoglycosides for Structure and Activity Relationship Studies.

Rational Design and Expedient Synthesis of Heparan Sulfate Mimetics from Natural Aminoglycosides for Structure and Activity Relationship Studies

Overcoming the Potential Window-Limited Functional Group Compatibility by Alternating Current Electrolysis

Rhodium‐Catalyzed Asymmetric Synthesis of 1,2‐Disubstituted Allylic Fluorides

Rhodium‐Catalyzed Asymmetric Synthesis of 1,2‐Disubstituted Allylic Fluorides

Heparan Sulfate-Mimicking Glycopolymers Bind SARS-CoV-2 Spike Protein in a Length- and Sulfation Pattern-Dependent Manner

Stereoselective 1,2-cis Furanosylations Catalyzed by Phenanthroline

Phenanthroline Catalysis in Stereoselective 1,2-cis Glycosylations

Heparan Sulfate Mimicking Glycopolymer Prevents Pancreatic β Cell Destruction and Suppresses Inflammatory Cytokine Expression in Islets under the Challenge of Upregulated Heparanase

Correction to “Phenanthroline-Catalyzed Stereoselective Formation of α-1,2-cis 2-Deoxy-2-Fluoro Glycosides”

Iridium‐Catalyzed Enantioselective Allylic Substitutions of Racemic, Branched Trichloroacetimidates with Heteroatom Nucleophiles: Formation of Allylic C−O, C−N, and C−S Bonds

A Mechanistic Probe into 1,2‐cis Glycoside Formation Catalyzed by Phenanthroline and Further Expansion of Scope

Phenanthroline-Catalyzed Stereoselective Formation of α-1,2-cis 2-Deoxy-2-Fluoro Glycosides

Collaborators (4)

Long Luo

H. Bernhard Schlegel

Vishaka Pathiranage

Alice Walker

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