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Hironori Hayashi

Assistant Professor

Tohoku University

Japan

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Research Interests

Virology

70%

Biochemistry

20%

Antiviral Research

50%

Sars-cov-2

40%

Chemical Biology

30%

Antiviral Therapy

30%

Molecular Biology

30%

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Articles19

An orally available P1′-5-fluorinated Mpro inhibitor blocks SARS-CoV-2 replication without booster and exhibits high genetic barrier

Article Link

Year:

2025

Binding of a potential antibacterial drug, mangiferin, to serine hydroxymethyltransferase from Enterococcus faecium

Article Link

Year:

2025

Elucidation of Postfusion Structures of the Measles Virus F Protein for the Structure-Based Design of Fusion Inhibitors

Article Link

Year:

2025

Helical peptides with disordered regions for measles viruses provide new generalized insights into fusion inhibitors

Article Link

Year:

2024

Janus-Type Immunofluorescent Probes and a Quantitative Immunoassay System

Article Link

Year:

2024

Structural and virologic mechanism of the emergence of resistance to Mpro inhibitors in SARS-CoV-2

Article Link

Year:

2024

SHIN-2 exerts potent activity against VanA-type vancomycin-resistant Enterococcus faecium in vitro by stabilizing the active site loop of serine hydroxymethyltransferase

Article Link

Year:

2024

Synthesis and Cytotoxicity of Cyclic Octapeptide Surugamides with Varied N-Acyl Moieties

Article Link

Year:

2024

Establishing an accurate and sensitive in vitro drug screening system for human adenovirus infection with human corneal cells

Article Link

Year:

2023

GRL-142 binds to and impairs HIV-1 integrase nuclear localization signal and potently suppresses highly INSTI-resistant HIV-1 variants

Article Link

Year:

2023

Identification of SARS-CoV-2 M-pro inhibitors containing P1' 4-fluorobenzothiazole moiety highly active against SARS-CoV-2

Article Link

Year:

2023

Helix-based screening with structure prediction using artificial intelligence has potential for the rapid development of peptide inhibitors targeting class I viral fusion

Article Link

Year:

2023

Antiviral Activity and Resistance Profile of the Novel HIV-1 Non-Catalytic Site Integrase Inhibitor JTP-0157602

Article Link

Year:

2022

Disseminated tuberculosis with paradoxical reactions caused by a Mycobacterium tuberculosis strain belonging to the Indo-Oceanic lineage: An imported case in Japan

Article Link

Year:

2022

Fluorine Modifications Contribute to Potent Antiviral Activity against Highly Drug-Resistant HIV-1 and Favorable Blood-Brain Barrier Penetration Property of Novel Central Nervous System-Targeting HIV-1 Protease Inhibitors In Vitro

Article Link

Year:

2022

Potent and biostable inhibitors of the main protease of SARS-CoV-2

Article Link

Year:

2022

Serine hydroxymethyltransferase as a potential target of antibacterial agents acting synergistically with one-carbon metabolism-related inhibitors

Article Link

Year:

2022

A small molecule compound with an indole moiety inhibits the main protease of SARS-CoV-2 and blocks virus replication

Article Link

Year:

2021

Mitochondrial dysfunction underlying sporadic inclusion body myositis is ameliorated by the mitochondrial homing drug MA-5

Article Link

Year:

2020

Collaborators1

Shinya Oishi

Kyoto University

JAPAN

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Hironori Hayashi

Assistant Professor

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Research Interests

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Articles19

An orally available P1′-5-fluorinated M<SUP>pro</SUP> inhibitor blocks SARS-CoV-2 replication without booster and exhibits high genetic barrier

Binding of a potential antibacterial drug, mangiferin, to serine hydroxymethyltransferase from<i> Enterococcus</i><i> faecium</i>

Elucidation of Postfusion Structures of the Measles Virus F Protein for the Structure-Based Design of Fusion Inhibitors

Helical peptides with disordered regions for measles viruses provide new generalized insights into fusion inhibitors

Janus-Type Immunofluorescent Probes and a Quantitative Immunoassay System

Structural and virologic mechanism of the emergence of resistance to M<sup>pro</sup> inhibitors in SARS-CoV-2

SHIN-2 exerts potent activity against VanA-type vancomycin-resistant<i> Enterococcus faecium</i> in vitro by stabilizing the active site loop of serine hydroxymethyltransferase

Synthesis and Cytotoxicity of Cyclic Octapeptide Surugamides with Varied<i> N</i>-Acyl Moieties

Establishing an accurate and sensitive in vitro drug screening system for human adenovirus infection with human corneal cells

GRL-142 binds to and impairs HIV-1 integrase nuclear localization signal and potently suppresses highly INSTI-resistant HIV-1 variants

Identification of SARS-CoV-2 M-pro inhibitors containing P1' 4-fluorobenzothiazole moiety highly active against SARS-CoV-2

Helix-based screening with structure prediction using artificial intelligence has potential for the rapid development of peptide inhibitors targeting class I viral fusion

Antiviral Activity and Resistance Profile of the Novel HIV-1 Non-Catalytic Site Integrase Inhibitor JTP-0157602

Disseminated tuberculosis with paradoxical reactions caused by a Mycobacterium tuberculosis strain belonging to the Indo-Oceanic lineage: An imported case in Japan

Fluorine Modifications Contribute to Potent Antiviral Activity against Highly Drug-Resistant HIV-1 and Favorable Blood-Brain Barrier Penetration Property of Novel Central Nervous System-Targeting HIV-1 Protease Inhibitors In Vitro

Potent and biostable inhibitors of the main protease of SARS-CoV-2

Serine hydroxymethyltransferase as a potential target of antibacterial agents acting synergistically with one-carbon metabolism-related inhibitors

A small molecule compound with an indole moiety inhibits the main protease of SARS-CoV-2 and blocks virus replication

Mitochondrial dysfunction underlying sporadic inclusion body myositis is ameliorated by the mitochondrial homing drug MA-5

Collaborators1

Shinya Oishi

How do I reach out?