Hiroshi Sakagami

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Meikai University School of Dentistry

Japan

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About

Professor Hiroshi Sakagami is a faculty member at Meikai University School of Dentistry in Japan. His research focuses on antitumor signaling pathways, the synthesis and bioactivities of various chemical compounds, and the relationship between salivary amino acids and periodontal disease. Recent studies have explored cytotoxicity in oral squamous cell carcinoma, the effects of green propolis extracts on oral microbiota, and medication-related osteonecrosis of the jaw in cancer patients.

Recent Grants

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Elucidation of the mechanism of selective toxicity of chromone derivatives to cancer cells

Open Date: 2020-04-01

Close Date: 2023-03-01

Grant: Close

Basic study searching the possibility of new 3-styrylchromone derivatives as new chemotherapeutic agents for oral cancers

Open Date: 2016-04-01

Close Date: 2019-03-01

Grant: Close

Exploration of salivary aging marker based on the collagen metabolites

Open Date: 2014-04-01

Close Date: 2016-03-01

Grant: Close

Basic research of exploration of autophagy-inducing therapy targeting human oral squamous cell carcinoma cell lines

Open Date: 2007-04-01

Close Date: 2010-03-01

Grant: Close

Clinical significance and application of polyphenols in the dentistry

Open Date: 2002-04-01

Close Date: 2005-03-01

Articles (20)

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University of Texas at El Paso

UNITED STATES

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Hiroshi Sakagami

Research Interests

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About

Recent Grants

Articles (20)

Design, synthesis and QSAR-based antitumor signaling pathway analysis of pyrazoline- benzenesulfonamides mediated by cytostatic G1 arrest

Indanone-based Mannich bases: Design, synthesis, in-silico molecular docking, ADME predictions and biological evaluation including carbonic anhydrases, acetylcholinesterase inhibition and cytotoxicities

Synthesis, Bioactivities, and in Silico Studies of Novel Benzo[ d ][1,3]Dioxole-Based Pyrazoline Sulfonamides

Age- and Periodontal Disease Independent Correlation of Salivary Amino Acids

Medication-related osteonecrosis of the jaw in patients with cancer using zoledronic acid and denosumab: Single-center retrospective study

Persistent Gingival Bleeding Related to Periodontal Disease

Efficacy of toothpaste containing Brazilian green propolis extracts with an optimal kaempferide/betuletol ratio for improving oral microbiota: A randomized, controlled, paired crossover study

Does Ortho-Substitution Enhance Cytotoxic Potencies in a Series of 3,5-Bis(benzylidene)-4-piperidones?

Medicines—Aims and Scope Updates

In vitro cytotoxicity of Withania somnifera (L.) roots and fruits on oral squamous cell carcinoma cell lines: a study supported by flow cytometry, spectral, and computational investigations

A Comparative Study of Tumor-Specificity and Neurotoxicity between 3-Styrylchromones and Anti-Cancer Drugs

Effects of Nitrurized Titanium on Microhardness and Human Dental Pulp Stem Cell Adhesion and Differentiation

Efficacy of Cryotherapy and Hangeshashinto for Radiation-induced Oral Stomatitis: Preliminary Study

Innate immune response of human periodontal ligament fibroblasts via the Dectin-1/Syk pathway

Effect of Underwater Exercise on Salivary Metabolites of Older Persons With Disability.

Prominent Anti-UVC Activity of Lignin Degradation Products.

Novel Unsymmetric 3,5-Bis(benzylidene)-4-piperidones That Display Tumor-Selective Toxicity.

Investigation of carbonic anhydrase inhibitory effects and cytotoxicities of pyrazole-based hybrids carrying hydrazone and zinc-binding benzenesulfonamide pharmacophores

Comparison of UVC Sensitivity and Dectin-2 Expression Between Malignant and Non-malignant Cells.

Dichloroacetyl Amides of 3,5-Bis(benzylidene)-4-piperidones Displaying Greater Toxicity to Neoplasms than to Non-Malignant Cells

Collaborators (5)

Kenjiro Bandow

Akira Sato

Keitaro Satoh

Yoshihiro Uesawa

Renato Aguilera

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