Hiroshi Shimizu

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Osaka University

Japan

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Hiroshi Shimizu is a professor at Osaka University, Japan. His research focuses on enzyme substrate specificity, metabolic flux analysis, and metabolic engineering in microbial systems, particularly in Synechocystis sp. PCC 6803 and Escherichia coli. Recent publications include methodologies for predicting enzyme activity and analyses of metabolic adjustments under varying conditions.

Recent Grants

Grant: Close

Intracellular metabolism control of the proton motive force

Open Date: 2016-06-30

Close Date: 2021-03-31

Grant: Close

Shin photosynthesis: re-optimization of the light energy conversion system

Open Date: 2016-06-30

Close Date: 2021-03-31

Grant: Close

The development of the rate-limiting point identification and flux optimization method by dynamic metabolic analysis of multi-story

Open Date: 2016-04-01

Close Date: 2019-03-31

Grant: Close

Study on inhibitory effect of high light on the cell growth and adaptation mechanism of cyanobacteria

Open Date: 2011-01-01

Close Date: 2012-12-31

Grant: Close

Quality Control of a Biodegradable Polymer using A Multivariable Controller, based on Metabolic Pathway Informaion

Open Date: 2000-01-01

Close Date: 2001-12-31

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Hokkaido University

JAPAN

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Hiroshi Shimizu

Research Interests

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About

Recent Grants

Articles (19)

Engineering anaerobic electron flow through heterologous rhodoquinone synthesis in model microbial and photosynthetic platforms

A method for predicting enzyme substrate specificity residues using homologous sequence information

Efficient selection of pyruvate decarboxylase sequences from database for high ethanol productivity in Synechocystis sp. PCC 6803

Glycolaldehyde affects the growth of and metabolic flux distribution in Synechocystis sp. PCC 6803

13C-metabolic flux analysis of respiratory chain disrupted strain ΔndhF1 of Synechocystis sp. PCC 6803

Modification of intracellular metabolism by expression of a C-terminal variant of phosphoribulokinase from Synechocystis sp. PCC 6803

Growth inhibition by ppc deletion is rescued by isocitrate dehydrogenase mutations in Escherichia coli

Metabolome analysis of metabolic burden in Escherichia coli caused by overexpression of green fluorescent protein and delta-rhodopsin

Identification of a novel NADPH generation reaction in the pentose phosphate pathway in Escherichia coli using mBFP

Effect of light fluctuations on photosynthesis and metabolic flux in Synechocystis sp. PCC 6803

Functional evaluation of non-oxidative glycolysis in Escherichia coli in the stationary phase under microaerobic conditions

Conversion of Mevalonate to Isoprenol Using Light Energy in Escherichia coli without Consuming Sugars for ATP Supply

Logistic Regression-Guided Identification of Cofactor Specificity-Contributing Residues in Enzyme with Sequence Datasets Partitioned by Catalytic Properties

13C metabolic flux analysis clarifies distinct metabolic phenotypes of cancer cell spheroid mimicking tumor hypoxia

Metabolic pathway design for growth-associated phenylalanine production using synthetically designed mutualism

Metabolic pathway engineering for the non-growth-associated succinate production in Escherichia coli based on flux solution space

Acceleration of target production in co‐culture by enhancing intermediate consumption through adaptive laboratory evolution

Improvement of 2,3-butanediol production by dCas9 gene expression system in Saccharomyces cerevisiae

Reactor control system in bacterial co‐culture based on fluorescent proteins using an Arduino‐based home‐made device

Collaborators (7)

Yoshihiro Toya

Jun Ishii

Masami Nakazawa

Fumio Matsuda

Kiyotaka Hara

Nobuyuki Okahashi

Tomoya Maeda

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