Hiroyasu Onaka

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Project Professor

Japan

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About

Hiroyasu Onaka is a Project Professor at Hiroyasu Onaka in Japan. His research areas focus on the functional characterization of biosynthetic and transporter genes, the discovery of bioactive compounds, and the biosynthetic incorporation of non-native building blocks in peptide products. He has contributed to recent advances in the study of bacterial organoarsenic natural products and the cytotoxic activities of various diterpenoids, showcasing his expertise in microbial interactions and secondary metabolism.

Recent Grants

Grant: Close

潜在的二次代謝活性化を誘発する複合培養法の作用機構解明

Open Date: 2018-04-01

Close Date: 2021-03-31

Grant: Close

試験管内人工生合成系を活用した擬天然物合成生物学

Open Date: 2016-06-30

Close Date: 2021-03-31

Grant: Close

翻訳系複素環ペプチド生合成遺伝子群の覚醒と新奇抗生物質生産システムへの適応

Open Date: 2013-04-01

Close Date: 2015-03-31

Grant: Close

Secondary metabolite Screening by combined-culture

Open Date: 2013-04-01

Close Date: 2017-03-31

Grant: Close

翻訳系を介した複素環含有ペプチド生合成機構を応用した抗生物質生産システムの構築

Open Date: 2011-04-01

Close Date: 2013-03-31

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Collaborators (6)

Tadashi EGUCHI

Tokyo Institute of Technology

JAPAN

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Shotaro Hoshino

Assistant Professor

Gakushuin University

JAPAN

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Alexander Vinogradov

Assistant professor

University of Tokyo

JAPAN

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Takefumi KURANAGA

Kyoto University

JAPAN

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Shumpei Asamizu

Project Associate Professor

Kobe University

JAPAN

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Shinichi Nishimura

Professor

Hiroshima University

JAPAN

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Hiroyasu Onaka

Research Interests

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About

Recent Grants

Articles (19)

Functional Characterization of Late-Stage Biosynthetic and Transporter Genes within the Biosynthetic Gene Cluster of the Organoarsenic Natural Product Bisenarsan

Griseolutein T from Streptomyces seoulensis, newly identified via combined-culture with Tsukamurella pulmonis, as an efficacious therapeutic agent against multidrug-resistant bacteria

Unlocking hidden bioactive compounds: from indolocarbazole and RiPP biosynthesis to the activation of cryptic secondary metabolism via microbial interactions

Three neo-Clerodane Diterpenoids from Tinospora cordifolia Stems and Their Arginase Inhibitory Activities

A new 3,4-seco-isopimarane and three new isopimarane diterpenoids from Kaempferia champasakensis collected from Vietnam and their cytotoxic activities.

Biosynthetic Incorporation of Non-native Aryl Acid Building Blocks into Peptide Products Using Engineered Adenylation Domains

Amoxetamide A, a new anoikis inducer, produced by combined-culture of Amycolatopsis sp. and Tsukamurella pulmonis

Five pimarane diterpenoids from Kaempferia champasakensis and their cytotoxic activities

Recent advances in the biosynthetic studies of bacterial organoarsenic natural products

Transcriptionally induced nucleoid-associated protein-like ccr1 in combined-culture serves as a global effector of Streptomyces secondary metabolism

Insights into Arsenic Secondary Metabolism in Actinomycetes from the Structure and Biosynthesis of Bisenarsan

SolS-catalyzed sulfoxidation of labionin to solabionin drives antibacterial activity of solabiomycins

NMR characterization of streptogramin B and L‐156,587, a non‐synergistic pair of the streptogramin family antibiotic complexes produced inductively by a combined culture of Streptomyces albogriseolus and Tsukamurella pulmonis

Differential Biosynthesis and Roles of Two Ferrichrome-Type Siderophores, ASP2397/AS2488053 and Ferricrocin, in Acremonium persicinum

Amycolapeptins A and B, Cyclic Nonadepsipeptides Produced by Combined-culture of Amycolatopsis sp. and Tsukamurella pulmonis

Accurate Broadcasting of Substrate Fitness for Lactazole Biosynthetic Pathway from Reactivity-Profiling mRNA Display

Promiscuous Enzymes Cooperate at the Substrate Level En Route to Lactazole A

Minimal lactazole scaffold for in vitro thiopeptide bioengineering

Bioactive properties of streptomyces may affect the dominance of Tricholoma matsutake in shiro

Collaborators (6)

Tadashi EGUCHI

Shotaro Hoshino

Alexander Vinogradov

Takefumi KURANAGA

Shumpei Asamizu

Shinichi Nishimura

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