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Hélène Munier-Lehmann

Institut Pasteur

France

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Research Interests

Biochemistry

60%

Pharmaceutical Chemistry

40%

Enzyme Engineering

20%

Inflammatory Biology

20%

Ligand Chemistry

20%

Molecular Interactions

20%

Protein-protein Interaction

20%

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Recent Grants

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Inserm permanent position

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Articles15

Design, synthesis, biophysical and biological evaluation of original condensed pyrrolopyrimidine and pyrrolopyridine ligands as anti-SARS-CoV-2 agents targeting G4

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Year:

2025

Synthesis, evaluation and mechanistic insights of novel IMPDH inhibitors targeting ESKAPEE bacteria

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Year:

2024

An equine iPSC-based phenotypic screening platform identifies pro- and anti-viral molecules against West Nile virus

Article Link

Year:

2024

A journey into the regulatory secrets of the de novo purine nucleotide biosynthesis

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Year:

2024

Insight into the role of the Bateman domain at the molecular and physiological levels through engineered IMP dehydrogenases

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Year:

2023

Interaction network among de novo purine nucleotide biosynthesis enzymes in Escherichia coli

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Year:

2023

SigH stress response mediates killing of <i>Mycobacterium tuberculosis</i> by activating nitronaphthofuran prodrugs via induction of Mrx2 expression

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Year:

2023

Discovery of Bis-Imidazoline Derivatives as New CXCR4 Ligands

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Year:

2023

Novel Antiviral Molecules against Ebola Virus Infection

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Year:

2023

Steroid hormone catabolites activate the pyrin inflammasome through a non-canonical mechanism

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Year:

2022

Structural basis for the allosteric inhibition of UMP kinase from Gram‐positive bacteria, a promising antibacterial target

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Year:

2022

Structure-aided optimization of non-nucleoside M. tuberculosis thymidylate kinase inhibitors

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Year:

2021

SARS-CoV-2 Nsp3 unique domain SUD interacts with guanine quadruplexes and G4-ligands inhibit this interaction

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Year:

2021

2-((3,5-Dinitrobenzyl)thio)quinazolinones: Potent Antimycobacterial Agents Activated by Deazaflavin (F<sub>420</sub>)-Dependent Nitroreductase (Ddn).

Article Link

Year:

2020

Endeavors towards transformation of M. tuberculosis thymidylate kinase (MtbTMPK) inhibitors into potential antimycobacterial agents

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Year:

2020

Collaborators12

Timothy P. O’Sullivan

University College Cork

IRELAND

Sylvain Baize

INSERM

FRANCE

Jana Sopkova-de Oliveira Santos

Université de Caen Normandie

FRANCE

Anne Brelot

INSERM

FRANCE

Bertrand raynal

Institut Pasteur

FRANCE

Brigitte Gicquel

Professor

Institut Pasteur

FRANCE

Marcelo Guerin

Professor

SPAIN

Noelia Alonso-Rodríguez

University of Oslo

NORWAY

Lionel Guittat

LOB - Laboratoire d’Optique et Biosciences CNRS UMR7645 – INSERM U1182

FRANCE

Quentin Giai Gianetto

Institut Pasteur

FRANCE

Patrick Bron

University of Montpellier

FRANCE

ANASTASSIA KOMAROVA

Université Paris Cité

FRANCE

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