Héléne Toinét Cronjé

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Københavns Universitet

Denmark

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Plasma proteomics for identification of non-invasive dementia risk markers

Open Date: 2021-09-01

Close Date: 2025-08-01

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Collaborators (13)

Tibor V. Varga

Københavns Universitet

DENMARK

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Marie-Joe Dib

Imperial College London

UNITED KINGDOM

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Roxane de La Harpe

Chief resident

Lausanne University Hospital

SWITZERLAND

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Susanna Larsson

Karolinska Institutet

SWEDEN

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Benjamin Woolf

University of Bristol

UNITED KINGDOM

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Majken Karoline Jensen

Københavns Universitet

DENMARK

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Thea Otte Andersen

Københavns Universitet

DENMARK

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Dipender Gill

Imperial College London

UNITED KINGDOM

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Jorge R. Kizer

UNITED STATES

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Alexandros Katsiferis

Københavns Universitet

DENMARK

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Ioanna Tzoulaki

UNITED KINGDOM

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Jingxian Huang

Imperial College London

UNITED KINGDOM

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Stephen Burgess

University of Cambridge

UNITED KINGDOM

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Héléne Toinét Cronjé

Research Interests

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Recent Grants

Articles (26)

Unravelling the Relationship Between Height, Lean Mass, Alzheimer’s Disease and Cognition Through Mendelian Randomization

Search for common genetic variants to allow reliable Mendelian randomization investigations into ketone metabolism.

Associations of Genetically Predicted NPR3 and NPR2 Perturbation and Preeclampsia Risk: A Two-Sample Mendelian Randomization Analysis.

Evaluating the Cardiometabolic Efficacy and Safety of Lipoprotein Lipase Pathway Targets in Combination With Approved Lipid-Lowering Targets: A Drug Target Mendelian Randomization Study.

Circulating sphingolipids in relation to cognitive decline and incident dementia: The Cardiovascular Health Study.

Comparison of caffeine consumption behavior with plasma caffeine levels as exposure measures in drug-target Mendelian randomization.

Proteomic Signatures of Genetically Predicted and Pharmacologically Observed PCSK9 Inhibition.

Genetic investigation into the broad health implications of caffeine: evidence from phenome-wide, proteome-wide and metabolome-wide Mendelian randomization.

Cerebrospinal Fluid C1-Esterase Inhibitor and Tie-1 Levels Affect Cognitive Performance: Evidence from Proteome-Wide Mendelian Randomization.

Cerebrospinal and Brain Proteins Implicated in Neuropsychiatric and Risk Factor Traits: Evidence from Mendelian Randomization.

Incorporating biological and clinical insights into variant choice for Mendelian randomisation: examples and principles.

Mendelian Randomization Applied to Neurology: Promises and Challenges

Common pitfalls in drug target Mendelian randomization and how to avoid them.

HbA1c comparable to fasting glucose in the external validation of the African Diabetes Risk Score and other established risk prediction models in Black South Africans.

Appraising the causal relationship between plasma caffeine levels and neuropsychiatric disorders through Mendelian randomization

Cardiovascular Efficacy of Lipid-Lowering Drug Targets Is Not Entirely Explained by Apolipoprotein B Reduction: Mendelian Randomization Evidence.

Serum NfL and GFAP are associated with incident dementia and dementia mortality in older adults: The cardiovascular health study.

Renoprotective effects of genetically proxied fibroblast growth factor 21: Mendelian randomization, proteome-wide and metabolome-wide association study.

Assessing racial bias in type 2 diabetes risk prediction algorithms.

Plasma Proteomic Risk Markers of Incident Type 2 Diabetes Reflect Physiologically Distinct Components of Glucose-Insulin Homeostasis.

Genetic evidence implicating natriuretic peptide receptor-3 in cardiovascular disease risk: a Mendelian randomization study.

Role of Clonal Hematopoiesis of Indeterminant Potential-Related Germline <i>TET2</i> Variation in Inflammation and Cardiovascular Disease Risk: A Mendelian Randomization Study.

Caffeine Intake, Plasma Caffeine Level, and Kidney Function: A Mendelian Randomization Study

A drug target for erectile dysfunction to help improve fertility, sexual activity, and wellbeing: mendelian randomisation study.

Sphingomyelins and ceramides: possible biomarkers for dementia?

The association between an energy-adjusted dietary inflammatory index and inflammation in rural and urban Black South Africans

Collaborators (13)

Tibor V. Varga

Marie-Joe Dib

Roxane de La Harpe

Susanna Larsson

Benjamin Woolf

Majken Karoline Jensen

Thea Otte Andersen

Dipender Gill

Jorge R. Kizer

Alexandros Katsiferis

Ioanna Tzoulaki

Jingxian Huang

Stephen Burgess

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